孕期母亲吸烟：1980 - 1983年密苏里州与先天性畸形无关联。
Maternal smoking during pregnancy: no association with congenital malformations in Missouri 1980-83.
作者信息
Malloy M H, Kleinman J C, Bakewell J M, Schramm W F, Land G H
机构信息
Prevention Research Program, National Institute of Child Health and Human Development, Bethesda, MD 20892.
出版信息
Am J Public Health. 1989 Sep;79(9):1243-6. doi: 10.2105/ajph.79.9.1243.
Abstract
Using a multisource birth defects registry developed by the Missouri Center for Health Statistics for the years 1980-83, we examined the relation between maternal smoking during pregnancy and the occurrence of congenital malformations. There were 288,067 live singleton births in this data set of which 10,223 had one or more congenital malformations. When adjusted for potential confounders the odds ratio for congenital malformations in the infants of women who smoked during pregnancy was not increased (odds ratio = 0.98, 95% confidence interval = 0.94 - 1.03). We examined the relation between smoking and groups of malformations using the International Classification of Diseases, 9th Revision, as well as analyzing for certain specific malformations within each group and found no increased risk for infants of smokers.
摘要
利用密苏里州卫生统计中心在1980 - 1983年期间建立的多源出生缺陷登记系统，我们研究了孕期母亲吸烟与先天性畸形发生之间的关系。在这个数据集中，有288,067例单胎活产，其中10,223例有一个或多个先天性畸形。在对潜在混杂因素进行调整后，孕期吸烟女性所生婴儿出现先天性畸形的比值比没有增加（比值比 = 0.98，95%置信区间 = 0.94 - 1.03）。我们使用《国际疾病分类》第九版研究了吸烟与畸形组之间的关系，并对每组中的某些特定畸形进行了分析，结果发现吸烟者的婴儿没有增加风险。
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