Slone Epidemiology Center at Boston University, 1010 Commonwealth Ave., Boston, MA 02215, USA.
Int J Environ Res Public Health. 2013 Aug 2;10(8):3263-81. doi: 10.3390/ijerph10083263.
This study was conducted to assess the association between the risks of spina bifida (SB) in relation to cigarette, alcohol, and caffeine consumption by women during the first month of pregnancy. Between 1988-2012, this multi-center case-control study interviewed mothers of 776 SB cases and 8,756 controls about pregnancy events and exposures. We evaluated cigarette smoking, frequency of alcohol drinking, and caffeine intake during the first lunar month of pregnancy in relation to SB risk. Logistic regression models were used to calculate adjusted odds ratios and 95% confidence intervals. Levels of cigarette smoking (1-9 and ≥10/day), alcohol intake (average ≥4 drinks/day) and caffeine intake (<1, 1, and ≥2 cups/day) were not likely to be associated with increased risk of SB. Further, results were similar among women who ingested less than the recommended amount of folic acid (400 μg/day).
本研究旨在评估女性在怀孕第一个月吸烟、饮酒和摄入咖啡因与脊柱裂（SB）风险之间的关联。在 1988 年至 2012 年间，这项多中心病例对照研究采访了 776 例 SB 病例和 8756 例对照的母亲，了解妊娠事件和暴露情况。我们评估了怀孕第一个月吸烟、饮酒和咖啡因摄入与 SB 风险之间的关系。采用逻辑回归模型计算调整后的优势比和 95%置信区间。吸烟水平（每天 1-9 支和≥10 支）、饮酒量（平均每天≥4 杯）和咖啡因摄入量（<1、1 和≥2 杯/天）与 SB 风险增加无关。此外，在叶酸摄入量低于推荐量（400μg/天）的女性中，结果也相似。
