美国成年人尿中双酚A、邻苯二甲酸酯代谢物与身体组成，1999 - 2006年美国国家健康与营养检查调查
Urinary bisphenol-A, phthalate metabolites and body composition in US adults, NHANES 1999-2006.
作者信息
Corbasson Iris, Hankinson Susan E, Stanek Edward J, Reeves Katherine W
机构信息
a Department of Biostatistics and Epidemiology , University of Massachusetts Amherst , Amherst , MA , USA.
出版信息
Int J Environ Health Res. 2016 Oct-Dec;26(5-6):606-17. doi: 10.1080/09603123.2016.1233524. Epub 2016 Sep 19.
BACKGROUND
Exposure to bisphenol-A (BPA) and phthalates is highly prevalent. Prior studies have not assessed associations between urinary levels of BPA and phthalate metabolites and body composition.
METHODS
National Health and Nutrition Examination Survey (NHANES) data from 1999 to 2006 on adults aged ≥20 were analyzed by linear regression for associations between urinary BPA, monoethyl phthalate, monobutyl phthalate (MBP), monoethylhexyl phthalate (MEHP), and monobenzyl phthalate (MBzP) and lean mass, fat mass, and percent body fat.
RESULTS
BPA and phthalate metabolites were not independently associated with fat mass or percent body fat. Significant inverse associations were observed with lean mass, with the strongest association observed for BPA in men (mean lean mass 1.39 kg lower for quartile 4 vs. quartile 1, p trend = 0.02).
CONCLUSIONS
BPA and some phthalates could have important, negative effects on muscle and may affect conditions related to deficits in lean mass, though additional research is needed.
背景
双酚A（BPA）和邻苯二甲酸盐的暴露非常普遍。先前的研究尚未评估尿中BPA和邻苯二甲酸酯代谢物水平与身体成分之间的关联。
方法
对1999年至2006年美国国家健康与营养检查调查（NHANES）中年龄≥20岁成年人的数据进行线性回归分析，以研究尿中BPA、邻苯二甲酸单乙酯、邻苯二甲酸单丁酯（MBP）、邻苯二甲酸单（2-乙基己基）酯（MEHP）和邻苯二甲酸单苄酯（MBzP）与瘦体重、脂肪量和体脂百分比之间的关联。
结果
BPA和邻苯二甲酸酯代谢物与脂肪量或体脂百分比无独立关联。观察到与瘦体重存在显著负相关，男性中BPA的相关性最强（四分位数4与四分位数1相比，平均瘦体重低1.39千克，p趋势=0.02）。
结论
BPA和某些邻苯二甲酸盐可能对肌肉有重要的负面影响，并可能影响与瘦体重不足相关的状况，不过仍需进一步研究。
Zotero 插件