Nagalski Andrzej, Kozinski Kamil, Wisniewska Marta B
Laboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
Laboratory of Molecular Neurobiology, Centre of New Technologies, University of Warsaw, 02-097 Warsaw, Poland.
Int J Biochem Cell Biol. 2016 Nov;80:19-30. doi: 10.1016/j.biocel.2016.09.012. Epub 2016 Sep 17.
The association between mental disorders and diabetes has a long history. Recent large-scale, well-controlled epidemiological studies confirmed a link between diabetes and psychiatric illnesses. The scope of this review is to summarize our current understanding of this relationship from a molecular perspective. We first discuss the potential contribution of diabetes-associated metabolic impairments to the etiology of mental conditions. Then, we focus on possible shared molecular risk factors and mechanisms. Simple comorbidity, shared susceptibility loci, and common pathophysiological processes in diabetes and mental illnesses have changed our traditional way of thinking about mental illness. We conclude that schizophrenia and affective disorders are not limited to an imbalance in dopaminergic and serotoninergic neurotransmission in the brain. They are also systemic disorders that can be considered, to some extent, as metabolic disorders.
精神障碍与糖尿病之间的关联由来已久。近期大规模、严格控制的流行病学研究证实了糖尿病与精神疾病之间的联系。本综述的范围是从分子角度总结我们目前对这种关系的理解。我们首先讨论糖尿病相关代谢损伤对精神疾病病因的潜在影响。然后，我们关注可能共同存在的分子风险因素和机制。糖尿病和精神疾病中的单纯共病、共同的易感基因座以及共同的病理生理过程改变了我们对精神疾病的传统思维方式。我们得出结论，精神分裂症和情感障碍不仅局限于大脑中多巴胺能和5-羟色胺能神经传递的失衡。它们也是全身性疾病，在某种程度上可被视为代谢性疾病。
