Okła Karolina, Wertel Iwona, Polak Grzegorz, Surówka Justyna, Wawruszak Anna, Kotarski Jan
a Department of Oncological Gynaecology and Gynaecology , Medical University , Lublin , Poland.
b Department of Biochemistry and Molecular Biology , Medical University , Lublin , Poland.
Int Rev Immunol. 2016 Sep 2;35(5):372-385. doi: 10.1080/08830185.2016.1206097. Epub 2016 Sep 19.
Cancers are complex masses of malignant cells and nonmalignant cells that create the tumor microenvironment (TME). Non-transformed cells of the TME such as tumor-associated macrophages (TAMs) and myeloid-derived suppressor cells (MDSCs) have been observed in the TME of ovarian cancer (OC) patients. Although these subsets may contribute to each step of carcinogenesis and are commonly associated with poor prognosis, still little is known about creation of the protumor microenvironment in OC. In this review, we focused on the nature and prognostic significance of TAMs and MDSCs in OC patients. Moreover, we discuss the main problems and challenges that must be overcome by researchers and clinicians to enrich our knowledge about the immunosuppressive microenvironment of cancers.
癌症是由恶性细胞和非恶性细胞组成的复杂肿块，它们共同构成肿瘤微环境（TME）。在卵巢癌（OC）患者的肿瘤微环境中，已观察到肿瘤微环境中的非转化细胞，如肿瘤相关巨噬细胞（TAM）和髓系来源的抑制细胞（MDSC）。尽管这些亚群可能参与致癌作用的各个步骤，且通常与预后不良相关，但对于卵巢癌中原肿瘤微环境的形成仍知之甚少。在本综述中，我们重点关注卵巢癌患者中肿瘤相关巨噬细胞和髓系来源抑制细胞的性质及预后意义。此外，我们还讨论了研究人员和临床医生为丰富我们对癌症免疫抑制微环境的认识而必须克服的主要问题和挑战。
