a School of Pharmacy Engineering , Shenyang Pharmaceutical University , Shenyang , PR China.
Pharm Dev Technol. 2018 Sep;23(7):674-681. doi: 10.1080/10837450.2016.1238483. Epub 2016 Oct 25.
Astaxanthin oleoresin (AO) has a number of beneficial physiological functions. However, its sensitivity to light, heat, oxygen and gastric fluids has limited its application. In this paper, we describe the preparation of AO enteric microcapsules by coacervation to improve its stability and enteric solubility, and evaluate their efficacy by measuring the drug loading, encapsulation efficiency, optical microscopic appearance, stability, in vitro release and bioavailability. The results obtained showed that the AO enteric microcapsules possessed a high encapsulation efficiency (85.9%), a satisfactory in vitro release profile, and the ability of the microencapsulated AO to resist the effects of light, heat and oxygen was improved by 2.2-fold, 3.1-fold and 2.4-fold, respectively, during storage. In addition, the bioavailability of AO microcapsules was approximately 1.29-fold higher than AO, which is important for pharmaceutical applications and as a functional food.
虾青素油树脂（AO）具有许多有益的生理功能。然而，其对光、热、氧和胃酸的敏感性限制了其应用。本文通过凝聚法制备 AO 肠溶微胶囊，以提高其稳定性和肠溶溶性，并通过测量载药量、包封率、光学显微镜外观、稳定性、体外释放和生物利用度来评价其效果。结果表明，AO 肠溶微胶囊具有较高的包封效率（85.9%），满意的体外释放曲线，并且在储存过程中，微囊化 AO 抵抗光、热和氧的影响的能力分别提高了 2.2 倍、3.1 倍和 2.4 倍。此外，AO 微胶囊的生物利用度约为 AO 的 1.29 倍，这对于药物应用和功能性食品很重要。
