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在手术室中使用二硫苏糖醇清除主动脉瓣生物膜上的细菌：1例由金黄色葡萄球菌和奇异变形杆菌引起的感染性心内膜炎病例

Use of Dithiothreitol to Dislodge Bacteria From the Biofilm on an Aortic Valve in the Operating Theatre: A Case of Infective Endocarditis Caused by Staphylococcus aureus and Proteus mirabilis.

作者信息

Rimoldi Sara G, De Vecchi Elena, Pagani Cristina, Zambelli Agostino, Di Gregorio Annamaria, Bosisio Enrica, Vanelli Paolo, Scrofani Roberto, Gismondo Maria R, Cagnoni Giovanni, Antona Carlo

机构信息

Laboratorio di Microbiologia Clinica, Virologia e Diagnostica delle Bioemergenze, ASST Fatebenefratelli Sacco-Polo Universitario, Milan, Italy.

Laboratorio di Analisi Chimico-Cliniche e Microbiologiche-IRCCS Istituto Ortopedico Galeazzi, Milan, Italy.

出版信息

Ann Thorac Surg. 2016 Oct;102(4):e357-9. doi: 10.1016/j.athoracsur.2016.03.023.

DOI:10.1016/j.athoracsur.2016.03.023
PMID:27645982
Abstract

This is the first reported case of 2 biofilm-producing bacteria, Staphylococcus aureus and Proteus mirabilis, identified from an aortic valve using an innovative device with dithiothreitol solution, able to dislodge bacterial biofilm. The method is usable in the operating theatre and recommended in infective endocarditis nonresponders to empiric therapy.

摘要

这是首例报告的使用含二硫苏糖醇溶液的创新装置从主动脉瓣中鉴定出两种产生物膜细菌——金黄色葡萄球菌和奇异变形杆菌的病例，该装置能够去除细菌生物膜。该方法可在手术室使用，推荐用于对经验性治疗无反应的感染性心内膜炎患者。

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Bacteria Living in Biofilms in Fluids: Could Chemical Antibiofilm Pretreatment of Culture Represent a Paradigm Shift in Diagnostics?液体中生物膜内的细菌：培养物的化学抗生物膜预处理能否代表诊断学的范式转变？
Microorganisms. 2024 Jan 26;12(2):259. doi: 10.3390/microorganisms12020259.
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Commentary: Dithiothreitol (DTT), When Used as Biofilm Detaching Method to Diagnose Implant-Associated Infections, Does Not Affect Microorganisms' Viability, According to the Current Literature.
评论：根据当前文献，当使用二硫苏糖醇（DTT）作为生物膜分离方法来诊断植入物相关感染时，不会影响微生物的生存能力。
Front Microbiol. 2022 Feb 24;12:814945. doi: 10.3389/fmicb.2021.814945. eCollection 2021.
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Germs. 2020 Sep 1;10(3):229-239. doi: 10.18683/germs.2020.1209. eCollection 2020 Sep.
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