Ioannou Petros, Vougiouklakis Georgios
MD, MSc, PhD, Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Stavrakia and Voutes crossroad, Heraklion, PC 71110, Crete, Greece.
Department of Internal Medicine & Infectious Diseases, University Hospital of Heraklion, Stavrakia and Voutes crossroad, Heraklion, PC 71110, Crete, Greece.
Germs. 2020 Sep 1;10(3):229-239. doi: 10.18683/germs.2020.1209. eCollection 2020 Sep.
spp. are members of the Enterobacteriaceae family and are Gram-negative, rod-shaped bacteria known to mainly cause urinary tract infections (UTIs) in humans. However, even though scarce evidence exists suggesting their potential to cause infective endocarditis (IE), a study summarizing the existing evidence is lacking. The purpose of this study was to systemically review all published cases of IE by species in the literature. A systematic review of PubMed, Scopus and Cochrane Library (through 5 May 2020) for studies providing epidemiological, clinical and microbiological data as well as data on treatment and outcomes of IE by species was performed. A total of 16 studies, containing data of 16 patients, were included. A prosthetic valve was present in 25%, while the most common causative pathogen was . Aortic valve was the most common infected site in 33.3%, followed by mitral valve in 26.7%. Diagnosis was set with transesophageal echocardiography in 37.5%, and transthoracic echocardiography in 25%, while the diagnosis was set at autopsy in 25%. Fever and sepsis were present in 100% and 84.6%, respectively. Aminoglycosides and cephalosporins were the most common antimicrobials used for treatment. Clinical cure was noted in 62.5%, while overall mortality was 43.8%. This systematic review describes IE by species in detail and provides information on epidemiology, clinical presentation, treatment and outcomes.
[具体菌属名称]属于肠杆菌科，是革兰氏阴性、杆状细菌，主要导致人类尿路感染（UTIs）。然而，尽管现有证据稀少，提示它们可能导致感染性心内膜炎（IE），但缺乏一项总结现有证据的研究。本研究的目的是系统回顾文献中所有已发表的由[具体菌属名称]引起的IE病例。对PubMed、Scopus和Cochrane图书馆（截至2020年5月5日）进行系统回顾，以查找提供关于由[具体菌属名称]引起的IE的流行病学、临床和微生物学数据以及治疗和结局数据的研究。共纳入16项研究，包含16例患者的数据。25%的患者存在人工瓣膜，而最常见的致病病原体是[具体菌属名称]。33.3%的患者中主动脉瓣是最常见的感染部位，其次是二尖瓣，占26.7%。37.5%的患者通过经食管超声心动图确诊，25%通过经胸超声心动图确诊，25%在尸检时确诊。分别有100%的患者出现发热和84.6%的患者出现败血症。氨基糖苷类和头孢菌素是最常用的治疗抗菌药物。62.5%的患者有临床治愈，而总死亡率为43.8%。本系统回顾详细描述了由[具体菌属名称]引起的IE，并提供了关于流行病学、临床表现、治疗和结局的信息。
