Jeong In Du, Park Moo In
Department of Internal Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, Korea.
Department of Internal Medicine, Kosin University Gospel Hospital, Kosin University College of Medicine, Busan, Korea.
Korean J Gastroenterol. 2016 Sep 25;68(3):127-31. doi: 10.4166/kjg.2016.68.3.127.
The prevalence of gastroesophageal reflux disease (GERD) and the incidence of some of its complications have risen strikingly over the last few decades. With the increase in our understanding of the pathophysiology of GERD along with the development of proton pump inhibitors, the diagnostic and therapeutic approaches to GERD have changed dramatically over the past decade. However, GERD still poses a problem to many clinicians since the spectrum of the disease has evolved to encompass more challenging presentations such as refractory GERD and extra-esophageal manifestations. The aim of this article is to provide a review of available current translational research on GERD. This review includes acid pocket, ambulatory pH monitoring, impedance pH monitoring, mucosa impedance, and high resolution manometry. This article discusses current translational research on GERD.
在过去几十年中，胃食管反流病（GERD）的患病率及其一些并发症的发生率显著上升。随着我们对GERD病理生理学认识的增加以及质子泵抑制剂的发展，在过去十年中GERD的诊断和治疗方法发生了巨大变化。然而，GERD仍然给许多临床医生带来问题，因为该疾病的范围已经演变，包括更具挑战性的表现，如难治性GERD和食管外表现。本文的目的是对现有的关于GERD的当前转化研究进行综述。该综述包括酸袋、动态pH监测、阻抗pH监测、黏膜阻抗和高分辨率测压法。本文讨论了关于GERD的当前转化研究。
