氧化石墨烯纳米载体在治疗神经胶质瘤中的作用
The Role of Graphene Oxide Nanocarriers in Treating Gliomas.
作者信息
Wang Bin, Guo Hanfei, Xu Haiyang, Chen Yong, Zhao Gang, Yu Hongquan
机构信息
Department of Neurosurgery, The First Hospital of Jilin University, Changchun, China.
Cancer Center, The First Hospital of Jilin University, Changchun, China.
出版信息
Front Oncol. 2022 Jan 28;12:736177. doi: 10.3389/fonc.2022.736177. eCollection 2022.
Abstract
Gliomas are the most common primary malignant tumors of the central nervous system, and their conventional treatment involves maximal safe surgical resection combined with radiotherapy and temozolomide chemotherapy; however, this treatment does not meet the requirements of patients in terms of survival and quality of life. Graphene oxide (GO) has excellent physical and chemical properties and plays an important role in the treatment of gliomas mainly through four applications, viz. direct killing, drug delivery, immunotherapy, and phototherapy. This article reviews research on GO nanocarriers in the treatment of gliomas in recent years and also highlights new ideas for the treatment of these tumors.
摘要
胶质瘤是中枢神经系统最常见的原发性恶性肿瘤，其传统治疗方法包括最大程度的安全手术切除，联合放疗和替莫唑胺化疗；然而，这种治疗在生存和生活质量方面并不能满足患者的需求。氧化石墨烯（GO）具有优异的物理和化学性质，主要通过直接杀伤、药物递送、免疫治疗和光疗这四种应用在胶质瘤治疗中发挥重要作用。本文综述了近年来GO纳米载体在胶质瘤治疗方面的研究，并突出了治疗这些肿瘤的新思路。
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