Yang Yu-Ling, Lin Ke, Yang Li
State Key Laboratory of Biotherapy and Cancer Center/Collaborative Innovation Center for Biotherapy, West China Hospital, Sichuan University, Chengdu 610041, China.
Pharmaceutics. 2021 Nov 18;13(11):1951. doi: 10.3390/pharmaceutics13111951.
Photodynamic therapy (PDT) is a promising anticancer noninvasive method and has great potential for clinical applications. Unfortunately, PDT still has many limitations, such as metastatic tumor at unknown sites, inadequate light delivery and a lack of sufficient oxygen. Recent studies have demonstrated that photodynamic therapy in combination with other therapies can enhance anticancer effects. The development of new nanomaterials provides a platform for the codelivery of two or more therapeutic drugs, which is a promising cancer treatment method. The use of multifunctional nanocarriers for the codelivery of two or more drugs can improve physical and chemical properties, increase tumor site aggregation, and enhance the antitumor effect through synergistic actions, which is worthy of further study. This review focuses on the latest research progress on the synergistic enhancement of PDT by simultaneous multidrug administration using codelivery nanocarriers. We introduce the design of codelivery nanocarriers and discuss the mechanism of PDT combined with other antitumor methods. The combination of PDT and chemotherapy, gene therapy, immunotherapy, photothermal therapy, hyperthermia, radiotherapy, sonodynamic therapy and even multidrug therapy are discussed to provide a comprehensive understanding.
光动力疗法（PDT）是一种很有前景的非侵入性抗癌方法，具有巨大的临床应用潜力。不幸的是，PDT仍然存在许多局限性，如未知部位的转移性肿瘤、光传递不足和缺乏足够的氧气。最近的研究表明，光动力疗法与其他疗法联合使用可以增强抗癌效果。新型纳米材料的开发为两种或更多治疗药物的共递送提供了一个平台，这是一种很有前景的癌症治疗方法。使用多功能纳米载体共递送两种或更多药物可以改善物理和化学性质，增加肿瘤部位的聚集，并通过协同作用增强抗肿瘤效果，值得进一步研究。本综述重点关注使用共递送纳米载体同时进行多药给药对PDT协同增强作用的最新研究进展。我们介绍了共递送纳米载体的设计，并讨论了PDT与其他抗肿瘤方法联合使用的机制。文中讨论了PDT与化疗、基因治疗、免疫治疗、光热治疗、热疗、放射治疗、声动力治疗甚至多药治疗的联合应用，以提供全面的理解。
