Mendes Ramon Barreto, Dias Rosane Borges, Figueiredo Andreia Leal, Gurgel Clarissa Araújo, Santana Filho Manoel, Melo Leonardo Araújo, Trierveiler Marília, Cury Patrícia Ramos, Leonardi Rosalia, Dos Santos Jean Nunes
Postgraduate Program in Human Pathology, Oswaldo Cruz Foundation, Salvador, Bahia, Brazil.
Department of Public Health, School of Dentistry, Federal University of Bahia, Salvador, Bahia, Brazil.
J Oral Pathol Med. 2017 Apr;46(4):297-300. doi: 10.1111/jop.12501. Epub 2016 Oct 13.
Glypican-3 is a cell surface proteoglycan that is found in embrionary tissues, and there are no studies investigating this protein in odontogenic tumor. Thus, the aim of this study was to investigate glypican-3 in a series of aggressive and non-aggressive odontogenic tumors.
Fifty-nine cases of tumors were divided into aggressive odontogenic tumors (20 solid ameloblastomas, four unicystic ameloblastoma, 28 KOTs including five associated with Gorlin-Goltz syndrome) and non-aggressive odontogenic tumors (five adenomatoid odontogenic tumors and two calcifying cystic odontogenic tumors) and analyzed for glypican-3 using immunohistochemistry.
Glypican-3 was observed in seven solid ameloblastoma and eighteen keratocystic odontogenic tumors including three of the five syndromic cases, but there was no significant difference between syndromic and sporadic cases (P > 0.05; Fisher's exact Test). All cases of unicystic ameloblastoma (n = 4), adenomatoid odontogenic tumor (n = 5), and calcifying cystic odontogenic tumor (n = 2) were negative.
This provided insights into the presence of glypican-3 in odontogenic tumors. This protein distinguished aggressive from non-aggressive odontogenic tumors.
磷脂酰肌醇蛋白聚糖-3是一种在胚胎组织中发现的细胞表面蛋白聚糖，目前尚无关于该蛋白在牙源性肿瘤中的研究。因此，本研究的目的是在一系列侵袭性和非侵袭性牙源性肿瘤中研究磷脂酰肌醇蛋白聚糖-3。
59例肿瘤分为侵袭性牙源性肿瘤（20例实性成釉细胞瘤、4例单囊型成釉细胞瘤、28例角化囊性牙源性肿瘤，其中5例与戈林-戈尔茨综合征相关）和非侵袭性牙源性肿瘤（5例腺样牙源性肿瘤和2例牙源性钙化囊性肿瘤），采用免疫组织化学方法分析磷脂酰肌醇蛋白聚糖-3。
在7例实性成釉细胞瘤和18例角化囊性牙源性肿瘤中观察到磷脂酰肌醇蛋白聚糖-3，其中包括5例综合征病例中的3例，但综合征病例和散发病例之间无显著差异（P>0.05；Fisher精确检验）。所有单囊型成釉细胞瘤（n=4）、腺样牙源性肿瘤（n=5）和牙源性钙化囊性肿瘤（n=2）病例均为阴性。
这为牙源性肿瘤中磷脂酰肌醇蛋白聚糖-3的存在提供了见解。该蛋白可区分侵袭性和非侵袭性牙源性肿瘤。
