Gómez-Herrera Zaira, Molina-Frechero Nelly, Damián-Matsumura Pablo, Bologna-Molina Ronell
Department of Health Care, Metropolitan Autonomous University, Xochimilco, 04960 Mexico City, Mexico.
Department of Biology of Reproduction, Metropolitan Autonomous University, Iztapalapa, 09340 Mexico City, Mexico.
J Oral Maxillofac Pathol. 2018 Jan-Apr;22(1):98-103. doi: 10.4103/jomfp.JOMFP_151_17.
Proteoglycans (PGs) are essential for normal cellular development; however, alterations of their concentrations can promote tumor growth. To date, a limited number of studies report the presence of PGs in odontogenic tumors (OTs); therefore, the main purpose of this work is to gather the information published on the study of PGs. The search reported 26 articles referring to the presence of different PGs in distinct OTs from 1999 to May 2017. PGs seem to play an important role during OTs' development as they are involved in several tumor processes; however, the number of reports on the study of these molecules is low. Thus, more studies are necessary in order to gain a better understanding of the underlying pathophysiology of OTs.
蛋白聚糖（PGs）对正常细胞发育至关重要；然而，其浓度的改变会促进肿瘤生长。迄今为止，仅有少数研究报道了牙源性肿瘤（OTs）中存在蛋白聚糖；因此，本研究的主要目的是收集已发表的关于蛋白聚糖研究的信息。检索发现，从1999年至2017年5月，有26篇文章提及不同牙源性肿瘤中存在不同的蛋白聚糖。蛋白聚糖似乎在牙源性肿瘤的发生发展过程中发挥重要作用，因为它们参与了多个肿瘤相关过程；然而，关于这些分子的研究报道数量较少。因此，有必要开展更多研究，以便更好地了解牙源性肿瘤潜在的病理生理学机制。
