Takeuchi Hikaru, Taki Yasuyuki, Nouchi Rui, Yokoyama Ryoichi, Kotozaki Yuka, Nakagawa Seishu, Sekiguchi Atsushi, Iizuka Kunio, Yamamoto Yuki, Hanawa Sugiko, Araki Tsuyoshi, Makoto Miyauchi Carlos, Shinada Takamitsu, Sakaki Kohei, Nozawa Takayuki, Ikeda Shigeyuki, Yokota Susumu, Daniele Magistro, Sassa Yuko, Kawashima Ryuta
Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Division of Developmental Cognitive Neuroscience, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan; Division of Medical Neuroimaging Analysis, Department of Community Medical Supports, Tohoku Medical Megabank Organization, Tohoku University, Sendai, Japan; Department of Radiology and Nuclear Medicine, Institute of Development, Aging and Cancer, Tohoku University, Sendai, Japan.
Neuroimage. 2017 May 15;152:258-269. doi: 10.1016/j.neuroimage.2017.02.079. Epub 2017 Feb 28.
Brain connectivity is traditionally thought to be important for creativity. Here we investigated the associations of creativity measured by divergent thinking (CMDT) with resting-state functional magnetic imaging (fMRI) measures and their sex differences. We examined these relationships in the brains of 1277 healthy young adults. Whole-brain analyses revealed a significant interaction between verbal CMDT and sex on (a) regional homogeneity within an area from the left anterior temporal lobe (b) on the resting state functional connectivity (RSFC) between the mPFC and the left inferior frontal gyrus and (c) on fractional amplitude of low frequency fluctuations (fALFF) in several distinct areas, including the precuneus and middle cingulate gyrus, left middle temporal gyrus, right middle frontal gyrus, and cerebellum. These interactions were mediated by positive correlations in females and negative correlations in males. These findings suggest that greater CMDT in females is reflected by (a) regional coherence (regional homogeneity) of brain areas responsible for representing and combining concepts as well as (b) the efficient functional connection (RSFC) between the key areas for the default state of cognitive activity and speech production, and (c) greater spontaneous neural activity (fALFF) during the resting of brain areas involved in frontal lobe functions, default cognitive activities, and language functions. Furthermore, these findings suggest that the associations between creativity and resting state brain connectivity patterns are different between males and females.
传统上认为大脑连通性对创造力很重要。在此，我们研究了用发散思维测量的创造力（CMDT）与静息态功能磁共振成像（fMRI）测量值之间的关联及其性别差异。我们在1277名健康年轻成年人的大脑中考察了这些关系。全脑分析揭示了言语CMDT与性别之间在以下方面存在显著交互作用：（a）左前颞叶一个区域内的局部一致性；（b）内侧前额叶皮质（mPFC）与左下额回之间的静息态功能连接（RSFC）；（c）几个不同区域的低频波动分数振幅（fALFF），包括楔前叶和中扣带回、左颞中回、右额中回和小脑。这些交互作用在女性中由正相关介导，在男性中由负相关介导。这些发现表明，女性中更高的CMDT体现在：（a）负责表征和组合概念的脑区的区域连贯性（局部一致性）；（b）认知活动默认状态和言语产生关键区域之间有效的功能连接（RSFC）；（c）参与额叶功能、默认认知活动和语言功能的脑区在静息时更大的自发神经活动（fALFF）。此外，这些发现表明，创造力与静息态脑连通性模式之间的关联在男性和女性中有所不同。
