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子宫肌层细胞因子及其在分娩发动中的作用。

Myometrial cytokines and their role in the onset of labour.

作者信息

Sivarajasingam S P, Imami N, Johnson M R

机构信息

Department of Surgery and CancerImperial College London, Chelsea and Westminster Hospital, London, UK.

Department of MedicineImperial College London, London, UK.

出版信息

J Endocrinol. 2016 Dec;231(3):R101-R119. doi: 10.1530/JOE-16-0157. Epub 2016 Sep 19.

DOI:10.1530/JOE-16-0157
PMID:27647860
Abstract

Human labour is an inflammatory event, physiologically driven by an interaction between hormonal and mechanical factors and pathologically associated with infection, bleeding and excessive uterine stretch. The initiation and communicators of inflammation is still not completely understood; however, a key role for cytokines has been implicated. We summarise the current understanding of the nature and role of cytokines, chemokines and hormones and their involvement in signalling within the myometrium particularly during labour.

摘要

人类分娩是一个炎症过程，在生理上由激素和机械因素之间的相互作用驱动，在病理上与感染、出血和子宫过度扩张有关。炎症的起始和传播机制仍未完全明确；然而，细胞因子已被认为起着关键作用。我们总结了目前对细胞因子、趋化因子和激素的性质及作用的理解，以及它们在子宫肌层信号传导中的参与情况，特别是在分娩期间。

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