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肝移植后肝细胞癌孤立转移灶的肾上腺切除术:病例报告及文献综述

Adrenalectomy for solitary metastasis of Hepatocellular carcinoma post liver transplantation: Case report and literature review.

作者信息

Jalbani Imran Khan, Nazim Syed M, Tariq Muhammad Usman, Abbas Farahat

机构信息

Imran Khan Jalbani, Department of Surgery, Aga Khan University, Karachi, Pakistan.

Syed M Nazim, Department of Surgery, Aga Khan University, Karachi, Pakistan.

出版信息

Pak J Med Sci. 2016 Jul-Aug;32(4):1044-6. doi: 10.12669/pjms.324.10339.

DOI:10.12669/pjms.324.10339
PMID:27648064
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5017075/
Abstract

Liver transplantation (LT) is the treatment of choice for localized hepatocellular carcinoma (HCC) associated with cirrhosis. Extra hepatic metastasis is the most common cause of death in these patients. There is very little evidence regarding the natural history and treatment options for patients developing HCC recurrence after LT. Surgical resection offers a unique opportunity for solitary metastasis. We report a 61 year old male with solitary right adrenal metastasis 15 months post LT which was managed with open adrenalectomy. The patient is alive and disease free 24 months after the surgery. The case, histo-pathological findings and literature review is discussed.

摘要

肝移植(LT)是伴有肝硬化的局限性肝细胞癌(HCC)的首选治疗方法。肝外转移是这些患者最常见的死亡原因。关于肝移植后发生HCC复发患者的自然病史和治疗选择的证据非常少。手术切除为孤立性转移提供了独特的机会。我们报告了一名61岁男性,在肝移植后15个月出现孤立性右肾上腺转移,接受了开放性肾上腺切除术。术后24个月,患者存活且无疾病。本文讨论了该病例、组织病理学发现及文献复习。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead0/5017075/99ae3c123b8a/PJMS-32-1044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead0/5017075/99ae3c123b8a/PJMS-32-1044-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/ead0/5017075/99ae3c123b8a/PJMS-32-1044-g002.jpg

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本文引用的文献

1
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Dig Surg. 2014;31(6):428-35. doi: 10.1159/000370078. Epub 2015 Jan 7.
2
Epidemiology of hepatocellular carcinoma: consider the population.肝细胞癌的流行病学:从人群角度考虑。
J Clin Gastroenterol. 2013 Jul;47 Suppl(0):S2-6. doi: 10.1097/MCG.0b013e3182872f29.
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Aflatoxin B1-induced hepatocellular carcinoma in developing countries: Geographical distribution, mechanism of action and prevention.
移植后肝细胞癌复发的治疗策略。
World J Gastroenterol. 2022 Sep 14;28(34):4929-4942. doi: 10.3748/wjg.v28.i34.4929.
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The management of post-transplantation recurrence of hepatocellular carcinoma.移植后肝细胞癌复发的管理。
Clin Mol Hepatol. 2022 Jan;28(1):1-16. doi: 10.3350/cmh.2021.0217. Epub 2021 Oct 5.
发展中国家黄曲霉毒素B1诱发的肝细胞癌:地理分布、作用机制及预防
Oncol Lett. 2013 Apr;5(4):1087-1092. doi: 10.3892/ol.2013.1169. Epub 2013 Jan 31.
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Metachronous pulmonary and adrenal metastases after liver transplantation for hepatocarcinoma.肝癌肝移植术后肺和肾上腺异时性转移。
World J Surg Oncol. 2011 Nov 28;9(1):156. doi: 10.1186/1477-7819-9-156.
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Hepatitis C virus genotype 3a infection and hepatocellular carcinoma: Pakistan experience.丙型肝炎病毒基因型 3a 感染与肝细胞癌:巴基斯坦的经验。
World J Gastroenterol. 2009 Oct 28;15(40):5080-5. doi: 10.3748/wjg.15.5080.
6
Adrenal metastasis from hepatocellular carcinoma: radiofrequency ablation combined with adrenal arterial chemoembolization in six patients.肝细胞癌肾上腺转移:6例患者的射频消融联合肾上腺动脉化疗栓塞治疗
AJR Am J Roentgenol. 2009 Jun;192(6):W300-5. doi: 10.2214/AJR.08.1752.
7
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Transplant Proc. 2009 Apr;41(3):1067-9. doi: 10.1016/j.transproceed.2009.02.018.
8
Tumor recurrence after liver transplantation for hepatocellular carcinoma: recurrence pathway and prognostic factors.肝细胞癌肝移植术后肿瘤复发:复发途径及预后因素
Transplant Proc. 2007 Sep;39(7):2304-7. doi: 10.1016/j.transproceed.2007.06.059.
9
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