Mousavi Seyedeh Neda, Koohdani Fariba, Shidfar Farzad, Shafiei-Neek Leila
Department of Biochemistry and Nutrition, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran.
Department of Cellular and Molecular Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran.
J Family Reprod Health. 2016 Jun;10(2):85-91.
Maternal type and amounts of dietary fatty acids affect on reproductive process in the mice. The present study investigated the effects of maternal supplementation with different amounts of omega-6 or omega-9 during pregnancy on the number of offspring, sex-ratio and duration of gestation.
Eight-week-old female C57BL/6 mice were randomly assigned into four dietary groups including low omega-6 (16%; LO6), low omega-9 (16%; LO9), high omega-6 (45%; HO6) and high omega-9 (45%; HO9) during gestation. Number of offspring, sex-ratio and duration of pregnancy were compared among four dietary groups.
There was significant difference between LO6 and HO6 (p < 0.0001), LO9 and HO9 (p < 0.0001) groups in total number of pups. The number of female and male offspring were significantly different between LO6 and LO9 (p = 0.009 and p = 0.001, respectively), LO9 and HO9 (p = 0.01 and p = 0.025) groups. Duration of pregnancy was significantly higher in low fat diet than high fat diet groups (< 0.001).
High fat diet reduced number of pups, gestation duration and lead to early labor. Omega-9 fatty acids shifted sex of offspring to females.
母体膳食脂肪酸的类型和数量会影响小鼠的生殖过程。本研究调查了孕期母体补充不同量的ω-6或ω-9脂肪酸对后代数量、性别比例和妊娠期时长的影响。
将8周龄的雌性C57BL/6小鼠在妊娠期随机分为四个饮食组，包括低ω-6组（16%；LO6）、低ω-9组（16%；LO9）、高ω-6组（45%；HO6）和高ω-9组（45%；HO9）。比较四个饮食组之间的后代数量、性别比例和妊娠期时长。
LO6和HO6组（p < 0.0001）、LO9和HO9组（p < 0.0001）在幼崽总数上存在显著差异。LO6和LO9组（分别为p = 0.009和p = 0.001）、LO9和HO9组（p = 0.01和p = 0.025）的雌性和雄性后代数量存在显著差异。低脂饮食组的妊娠期时长显著高于高脂饮食组（< 0.001）。
高脂饮食会减少幼崽数量、缩短妊娠期并导致早产。ω-9脂肪酸会使后代性别偏向雌性。
