Wijarnpreecha Karn, Thongprayoon Charat, Panjawatanan Panadeekarn, Manatsathit Wuttiporn, Ungprasert Patompong
aDepartment of Internal Medicine, Bassett Medical Center, Cooperstown, New York bDepartment of Gastroenterology and Hepatology, University of Nebraska Medical Center, Omaha, Nebraska cDivision of Rheumatology, Department of Internal Medicine, Mayo Clinic, Rochester, Minnesota, USA dDepartment of Biochemistry, Faculty of Medicine, Chiang Mai University, Chiang Mai eDivision of Rheumatology, Department of Medicine, Faculty of Medicine Siriraj Hospital, Mahidol University, Bangkok, Thailand.
Eur J Gastroenterol Hepatol. 2016 Dec;28(12):1437-1442. doi: 10.1097/MEG.0000000000000754.
BACKGROUND/OBJECTIVES: Gallstone disease and its complications are common, particularly in Western populations. Recent studies have reported a significantly increased risk of gallstones among hepatitis C virus-infected patients. However, the data on patients with hepatitis B virus (HBV) infection are still limited. This meta-analysis was carried out with the aim of summarizing all available evidence.
A literature search was performed using MEDLINE and the EMBASE database from inception to May 2016. Studies that reported relative risks, odd ratios, or hazard ratios comparing the risk of gallstones among HBV-infected patients versus patients without HBV infection were included. Pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using a random-effect, generic inverse-variance method.
Nine studies fulfilled our eligibility criteria and were included in the analysis. We found no significant association between HBV infection and the risk of gallstones, with a pooled OR of 1.10 (95% CI, 0.91-1.33). The statistical heterogeneity was moderate, with an I of 69%. Subgroup analysis was carried out. The pooled OR of cross-sectional studies was 1.01 (95% CI, 0.91-1.12; I 0%), whereas the pooled OR of case-control studies was 1.53 (95% CI, 0.85-2.74; I 80%).
A significant association between HBV infection and the risk of gallstones was not observed in this study.
背景/目的：胆结石疾病及其并发症很常见，尤其是在西方人群中。最近的研究报告称，丙型肝炎病毒感染患者患胆结石的风险显著增加。然而，关于乙型肝炎病毒（HBV）感染患者的数据仍然有限。本荟萃分析旨在总结所有现有证据。
使用MEDLINE和EMBASE数据库进行文献检索，检索时间从数据库建立至2016年5月。纳入报告了比较HBV感染患者与未感染HBV患者患胆结石风险的相对风险、比值比或风险比的研究。采用随机效应、通用逆方差法计算合并比值比（OR）和95%置信区间（CI）。
九项研究符合我们的纳入标准并被纳入分析。我们发现HBV感染与胆结石风险之间无显著关联，合并OR为1.10（95%CI，0.91 - 1.33）。统计异质性为中度，I²为69%。进行了亚组分析。横断面研究的合并OR为1.01（95%CI，0.91 - 1.12；I² 0%），而病例对照研究的合并OR为1.53（95%CI，0.85 - 2.74；I² 80%）。
本研究未观察到HBV感染与胆结石风险之间存在显著关联。
