Safi Morteza, Mahjoob Mohammad Parsa, Nateghi Saeed, Khaheshi Isa, Akbarzadeh Mohammad Ali, Naderian Mohammadreza
Rom J Intern Med. 2017 Mar 1;55(1):23-27. doi: 10.1515/rjim-2016-0045.
Recent studies have confirmed the essential and paramount role of the L-Citrulline on the nitric oxide regulation and the endothelial function improvement.
In this cross-over clinical trial, thirty patients, diagnosed with coronary artery disease (CAD) and flow mediated dilation to nitroglycerin dependent vasodilation (FMD/NMD) ratio less than 1, were included. The patients were randomly divided into two groups of 15 patients and underwent treatment by L-Citrulline or placebo for 15 days, in 2 step protocol. The indicators of assessment in the current study were the ratio of the FMD/NMD and FMD value.
In the current cross-over clinical trial, the mean of FMD to NMD ratio and mean FMD value of all patients before starting the protocol were 0.91 ± 0.08 and 4.04 ± 0.51 mm, respectively. The final results of study showed that following L-Citrulline administration, mean FMD to NMD ratio and mean FMD value were enhanced to: 1.03 ± 0.09 and 4.96 ± 0.72 mm, respectively, which were statistically significant (P<0.001 and P<0.001, respectively). However, following placebo administration, mean FMD to NMD ratio and mean FMD value were receded to: 0.92 ± 0.09 and 4.06 ± 0.22 mm, respectively, which were not statistically significant (P = 0.75 and P = 0.89, respectively). Moreover, the improvement of mean FMD to NMD ratio (0.12 ± 0.02) and mean FMD value (0.92 ± 0.16 mm), following L-Citrulline administration, were statistically significant in comparison with the change of mean FMD to NMD ratio (0.01 ± 0.002) and mean FMD value (0.02 ± 0.003), following placebo administration (P<0.001 and P<0.001, respectively).
L-Citrulline treatment can lead to improvement of the endothelial function in patients diagnosed with CAD which are assessed via FMD to NMD ratio FMD value enhancements.
近期研究证实了L-瓜氨酸在一氧化氮调节和改善内皮功能方面的重要且关键作用。
在这项交叉临床试验中，纳入了30例被诊断为冠心病（CAD）且血流介导的舒张与硝酸甘油依赖性血管舒张（FMD/NMD）比值小于1的患者。患者被随机分为两组，每组15例，按照两步方案接受L-瓜氨酸或安慰剂治疗15天。本研究的评估指标为FMD/NMD比值和FMD值。
在当前的交叉临床试验中，所有患者在开始方案前FMD与NMD比值的平均值为0.91±0.08，FMD值的平均值为4.04±0.51mm。研究的最终结果显示，给予L-瓜氨酸后，FMD与NMD比值的平均值和FMD值分别提高到：1.03±0.09和4.96±0.72mm，具有统计学意义（分别为P<0.001和P<0.001）。然而，给予安慰剂后，FMD与NMD比值的平均值和FMD值分别降至：0.92±0.09和4.06±0.22mm，无统计学意义（分别为P = 0.75和P = 0.89）。此外，与给予安慰剂后FMD与NMD比值的变化（0.01±0.002）和FMD值的变化（0.02±0.003）相比，给予L-瓜氨酸后FMD与NMD比值的平均值（0.12±0.02）和FMD值的平均值（0.92±0.16mm）的改善具有统计学意义（分别为P<0.001和P<0.001）。
L-瓜氨酸治疗可通过FMD与NMD比值及FMD值的提高，改善被诊断为CAD患者的内皮功能。
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