Chatziralli Irini, Mitropoulos Panagiotis, Parikakis Efstratios, Niakas Dimitrios, Labiris Georgios
a Second Department of Ophthalmology , Ophthalmiatrion Athinon , Athens , Greece.
b Hellenic Open University , Faculty of Social Sciences , Patra , Greece.
Semin Ophthalmol. 2017;32(6):772-780. doi: 10.1080/08820538.2016.1181192. Epub 2016 Aug 10.
The purpose of this study was to evaluate the quality of life in patients with age-related macular degeneration (AMD) and compare it with that of healthy controls. Additionally, our study aims to investigate the possible risk factors for poor quality of life in AMD patients.
Participants in the study were 114 patients with AMD, 63 male and 51 female, mean-aged 76.5 ± 6.1 years. Demographic data, lifestyle factors, and medical history were recorded. All patients underwent a routine examination for AMD, including best-corrected visual acuity measurement, dilated fundoscopy and optical coherence tomography, and completed three questionnaires assessing quality of life (SF-36, EQ-5D, NEI VFQ-25). In addition, 100 controls, adjusted for gender and age, were included in the study. Risk factors for quality of life in AMD patients were investigated. Univariate analysis was performed using SPSS 22.0.
Patients with AMD scored lower in vision- and health-related quality-of-life questionnaires compared to controls. Risk factors associated with quality of life in patients with AMD were found to be the female gender, alcohol consumption, the presence of hypertension, diabetes mellitus, cardiovascular diseases, myosceletal problems, migraine, anxiety/depression, subretinal or intraretinal fluid, pigment epithelium detachment, previous treatment for AMD, visual acuity, the stage of the disease, and the integrity of the ellipsoid zone.
Patients with AMD presented lower quality of life in comparison with controls. Potential risk factors should be taken into account and clinicians should thus focus on the most vulnerable subgroups.
本研究旨在评估年龄相关性黄斑变性（AMD）患者的生活质量，并将其与健康对照组进行比较。此外，我们的研究旨在调查AMD患者生活质量差的可能危险因素。
本研究的参与者为114例AMD患者，其中男性63例，女性51例，平均年龄76.5±6.1岁。记录人口统计学数据、生活方式因素和病史。所有患者均接受了AMD的常规检查，包括最佳矫正视力测量、散瞳眼底镜检查和光学相干断层扫描，并完成了三份评估生活质量的问卷（SF-36、EQ-5D、NEI VFQ-25）。此外，研究纳入了100名根据性别和年龄进行调整的对照组。对AMD患者生活质量的危险因素进行了调查。使用SPSS 22.0进行单因素分析。
与对照组相比，AMD患者在视力和健康相关生活质量问卷中的得分较低。发现与AMD患者生活质量相关的危险因素包括女性、饮酒、高血压、糖尿病、心血管疾病、肌肉骨骼问题、偏头痛、焦虑/抑郁、视网膜下或视网膜内积液、色素上皮脱离、既往AMD治疗史、视力、疾病阶段和椭圆体带的完整性。
与对照组相比，AMD患者的生活质量较低。应考虑潜在的危险因素，因此临床医生应关注最脆弱的亚组。
