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眼表化学伤的当前和即将到来的治疗方法。

Current and Upcoming Therapies for Ocular Surface Chemical Injuries.

机构信息

Ophthalmic Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, Illinois, USA.

出版信息

Ocul Surf. 2017 Jan;15(1):48-64. doi: 10.1016/j.jtos.2016.09.002. Epub 2016 Sep 17.

DOI:10.1016/j.jtos.2016.09.002
PMID:27650263
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5191942/
Abstract

Chemical injuries frequently result in vision loss, disfigurement, and challenging ocular surface complications. Acute interventions are directed at decreasing the extent of the injury, suppressing inflammation, and promoting ocular surface re-epithelialization. Chronically, management involves controlling inflammation along with rehabilitation and reconstruction of the ocular surface. Future therapies aimed at inhibiting neovascularization and promoting ocular surface regeneration should provide more effective treatment options for the management of ocular chemical injuries.

摘要

化学性损伤常导致视力丧失、毁容和严重的眼表并发症。急性干预措施旨在减少损伤程度、抑制炎症和促进眼表再上皮化。慢性期的治疗包括控制炎症以及眼表的康复和重建。旨在抑制新生血管形成和促进眼表再生的未来疗法应为眼化学性损伤的治疗提供更有效的治疗选择。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf59/5191942/755df1ecef75/nihms817529f11.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf59/5191942/fef230ddb806/nihms817529f7.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf59/5191942/82a17495992f/nihms817529f8.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cf59/5191942/755df1ecef75/nihms817529f11.jpg

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Simultaneous in vivo imaging of blood and lymphatic vessel growth in Prox1-GFP/Flk1::myr-mCherry mice.在Prox1-GFP/Flk1::myr-mCherry小鼠中对血管和淋巴管生长进行同步体内成像。
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