Department of Clinical and Experimental Medicine, Rheumatology Section, Second University of Naples, II Policlinico, Building 3, Via Pansini 5, Naples, Italy.
Division of General and Bariatric Surgery, Second University of Naples, Naples, Italy.
Clin Exp Med. 2017 Aug;17(3):411-414. doi: 10.1007/s10238-016-0437-y. Epub 2016 Sep 20.
The aim of the study was to evaluate CXCL4 levels in undifferentiated connective tissue disease at risk for SSc (UCTD-SSc-risk) and confirm its increase and investigate its prognostic value. Serum CXCL4 levels were measured in 45 patients and 24 controls. CXCL4 was significantly higher in UCTD-SSc-risk patients than in controls. It resulted higher in patients with a shorter disease duration and in those lacking capillaroscopic alterations. We confirm that CXCL4 levels are increased in UCTD-risk-SSc patients. Further studies are needed to investigate the role of CXCL4 assessment in UCTD-risk-SSc.
本研究旨在评估未分化结缔组织病（UCTD）发生硬皮病（SSc）风险患者的趋化因子（CXCL4）水平，并证实其升高及其预后价值。共检测了 45 例患者和 24 例对照者的血清 CXCL4 水平。与对照组相比，UCTD-SSc 风险患者的 CXCL4 水平显著升高。该水平在疾病持续时间较短和无毛细血管镜改变的患者中更高。我们证实，UCTD-SSc 风险患者的 CXCL4 水平升高。需要进一步研究以探讨 CXCL4 评估在 UCTD-SSc 风险患者中的作用。
