通过磁共振成像研究局部主动脉顺应性：年龄、训练和冠状动脉疾病的影响。
Regional aortic compliance studied by magnetic resonance imaging: the effects of age, training, and coronary artery disease.
作者信息
Mohiaddin R H, Underwood S R, Bogren H G, Firmin D N, Klipstein R H, Rees R S, Longmore D B
机构信息
Magnetic Resonance Unit, National Heart Hospital, London.
出版信息
Br Heart J. 1989 Aug;62(2):90-6. doi: 10.1136/hrt.62.2.90.
Arterial compliance was measured in 70 healthy volunteers, 13 athletes, and 17 patients with coronary artery disease. Magnetic resonance images were acquired at end diastole and end systole through the ascending aorta, the aortic arch, and the descending thoracic aorta. Regional compliance was derived from the change in luminal area in a slice of known thickness and from the pulse pressure. Total arterial compliance was also measured from the left ventricular stroke volume and the pulse pressure. In the volunteers, mean (SD) regional compliance (microliters/mm Hg) was greatest in the ascending aorta (37 (18], lower in the arch (31 (15], and lowest in the descending aorta (18 (8], and it decreased with age. Compliance in the athletes was significantly higher than in their age matched controls (41 (16) versus 22 (11) microliters/mm Hg). In the patients with coronary artery disease it was significantly lower (12 (4) v 18 (10] than in age matched controls. Total arterial compliance also fell with age in those with coronary artery disease although there was more variation. The results suggest a possible role for compliance in the assessment of cardiovascular fitness and the detection of coronary artery disease.
对70名健康志愿者、13名运动员和17名冠心病患者进行了动脉顺应性测量。在舒张末期和收缩末期通过升主动脉、主动脉弓和降主动脉采集磁共振图像。局部顺应性由已知厚度切片的管腔面积变化和脉压得出。总动脉顺应性也通过左心室每搏输出量和脉压进行测量。在志愿者中，升主动脉的平均（标准差）局部顺应性（微升/毫米汞柱）最大（37 [18]），主动脉弓较低（31 [15]），降主动脉最低（18 [8]），且随年龄下降。运动员的顺应性显著高于年龄匹配的对照组（41 [16] 对 22 [11] 微升/毫米汞柱）。冠心病患者的顺应性显著低于年龄匹配的对照组（12 [4] 对 18 [10]）。冠心病患者的总动脉顺应性也随年龄下降，尽管变化更大。结果表明顺应性在评估心血管健康状况和检测冠心病方面可能具有作用。
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