Thornton C, Barrowcliffe M P, Konieczko K M, Ventham P, Doré C J, Newton D E, Jones J G
Division of Anaesthesia, Royal Perth Hospital, Western Australia.
Br J Anaesth. 1989 Jul;63(1):113-5. doi: 10.1093/bja/63.1.113.
The latency of the early cortical wave Nb of the auditory evoked response (AER) was compared with responses to Tunstall's isolated forearm test, while the concentration of nitrous oxide was progressively reduced during light anaesthesia in seven patients. A threshold Nb latency of 44.5 ms was chosen to discriminate between an early cortical AER containing three waves and that with two waves of longer latency. When Nb latency decreased below this threshold, four of the patients has positive responses, indicating awareness. The addition of a volatile anaesthetic abolished any response, and increased Nb latency to more than 44.5 ms. The three wave AER pattern, therefore, is associated with a depth of anaesthesia at which awareness occurs.
在七名患者的浅麻醉过程中，当一氧化二氮浓度逐渐降低时，将听觉诱发电位（AER）的早期皮质波Nb的潜伏期与对滕斯托尔孤立前臂试验的反应进行了比较。选择44.5毫秒的阈值Nb潜伏期来区分包含三个波的早期皮质AER和具有两个较长潜伏期波的AER。当Nb潜伏期降至该阈值以下时，四名患者有阳性反应，表明存在知晓。添加挥发性麻醉剂消除了任何反应，并使Nb潜伏期增加到超过44.5毫秒。因此，三相AER模式与发生知晓的麻醉深度相关。
