Bonnet F, Diallo A, Saada M, Belon M, Guilbaud M, Boico O
Département d'Anesthésie Réanimation No. II, Hôpital Henri Mondor, Creteil, France.
Br J Anaesth. 1989 Jul;63(1):93-6. doi: 10.1093/bja/63.1.93.
In order to assess the effect of spinal clonidine on tourniquet pain, 30 patients scheduled to undergo orthopaedic surgery under spinal anaesthesia were allocated randomly to two groups. Patients in group I (n = 15) received 0.5% isobaric bupivacaine 15 mg plus isotonic saline 1 ml. Patients in group II (n = 15) received 0.5% bupivacaine 15 mg plus clonidine 1 ml (150 micrograms). Sensory block was evaluated by pinprick and motor block with Bromage's scale. The presence of clonidine significantly prolonged the duration of sensory and motor block. Three patients in group I, but none in group II, experienced tourniquet pain. Hypotension and bradycardia were not worsened by spinal clonidine. The use of clonidine may be a useful technique to augment bupivacaine spinal block.
为评估脊髓可乐定对止血带疼痛的影响，将30例计划在脊髓麻醉下接受骨科手术的患者随机分为两组。第一组（n = 15）患者接受15 mg 0.5%等比重布比卡因加1 ml等渗盐水。第二组（n = 15）患者接受15 mg 0.5%布比卡因加1 ml可乐定（150微克）。通过针刺评估感觉阻滞，并使用 Bromage 评分评估运动阻滞。可乐定的存在显著延长了感觉和运动阻滞的持续时间。第一组有3例患者出现止血带疼痛，而第二组无此情况。脊髓可乐定并未使低血压和心动过缓加重。使用可乐定可能是增强布比卡因脊髓阻滞的一种有用技术。
