Bonnet F, Brun-Buisson V, Saada M, Boico O, Rostaing S, Touboul C
Département Anesthésie Réanimation no. 2, Hôpital Henri Mondor, Creteil, France.
Anesth Analg. 1989 May;68(5):619-22.
The effect of clonidine, an alpha 2 agonist, on sensory and motor blockade during spinal anesthesia was studied in 44 ASA physical status I II patients scheduled for orthopedic surgery. The patients were randomly allocated into three groups given 15 mg of 0.5% hyperbaric tetracaine (HT), within group I (N = 14) 1 ml isotonic saline, in group II (N = 15) 0.5 ml saline solution and 0.5 ml clonidine (75 micrograms), and in group III (N = 15) 1 ml clonidine (150 micrograms). Sensory blockade (SB) was evaluated by pinprick and motor blockade (MB) according to Bromage's scale. The level of SB was comparable in the three groups but the duration was different. The 75 micrograms clonidine was associated with 25% prolongation of SB at L2 and 29% prolongation of grade 3 MB Clonidine 150 micrograms prolonged the time of SB at L2 by 72% and grade 3 MB by 96%. Colloid infusion and the decrease in diastolic blood pressure were significantly greater in the clonidine 150 micrograms group compared to group I. A dose related prolongation of spinal anesthesia is demonstrated with clonidine.
在44例拟行骨科手术的美国麻醉医师协会（ASA）身体状况I-II级患者中，研究了α2激动剂可乐定对脊髓麻醉期间感觉和运动阻滞的影响。患者被随机分为三组，均给予15mg 0.5%的重比重丁卡因（HT），第一组（N = 14）给予1ml等渗盐水，第二组（N = 15）给予0.5ml盐水溶液和0.5ml可乐定（75微克），第三组（N = 15）给予1ml可乐定（150微克）。通过针刺评估感觉阻滞（SB），并根据布罗玛格量表评估运动阻滞（MB）。三组的感觉阻滞水平相当，但持续时间不同。75微克可乐定使L2水平的感觉阻滞延长25%，3级运动阻滞延长29%。150微克可乐定使L2水平的感觉阻滞时间延长72%，3级运动阻滞延长96%。与第一组相比，150微克可乐定组的胶体输注量和舒张压下降幅度明显更大。可乐定显示出与剂量相关的脊髓麻醉延长作用。
