Department of Dermatology, University Medical Center Mainz, Johannes Gutenberg-University, Mainz, Germany.
Institute for Immunology, University Medical Center Mainz, Johannes Gutenberg-University, Mainz, Germany.
Nanomedicine (Lond). 2016 Oct;11(20):2699-2709. doi: 10.2217/nnm-2016-0197. Epub 2016 Sep 21.
Treg cell-mediated immune suppression appears to represent a significant barrier to effective anticancer immune responses and their inactivation or removal is viewed as a potential therapeutic approach. Although suitable tools for selective Treg cell manipulation in man are missing, their number and function can be altered by a number of drugs and biologicals and by reprogramming tumor-infiltrating antigen presenting cells. Nanoparticles offer exceptional new options in drug and gene delivery by prolonging the circulation time of their cargo, protecting it from degradation and promoting its local accumulation in cells and tissues. In tumor therapy, the use of nanoparticles is expected to overcome limitations in drug delivery and provide novel means for cell-specific functional alteration. In this perspective, we summarize strategies suitable for interference with Treg-mediated suppression, discuss the potential use of nanoparticles for this purpose and identify additional, unexplored opportunities.
调节性 T 细胞介导的免疫抑制似乎代表了有效的抗肿瘤免疫反应的一个重大障碍，其失活或去除被视为一种潜在的治疗方法。虽然用于选择性调节性 T 细胞操作的合适工具在人类中尚不存在，但许多药物和生物制剂以及重新编程肿瘤浸润性抗原呈递细胞可以改变其数量和功能。纳米颗粒通过延长其货物的循环时间、保护其免受降解并促进其在细胞和组织中的局部积累，为药物和基因递送提供了特殊的新选择。在肿瘤治疗中，预计使用纳米颗粒将克服药物递送中的限制，并为细胞特异性功能改变提供新的手段。在这方面，我们总结了适合干扰调节性 T 细胞介导的抑制的策略，讨论了纳米颗粒在这方面的潜在用途，并确定了其他未被探索的机会。
