Makkonen T A, Borthen L, Heimdahl A, Joensuu H, Lehtonen O P, Nord C E
Department of Oral Surgery, University of Turku, Finland.
Br J Oral Maxillofac Surg. 1989 Aug;27(4):334-40. doi: 10.1016/0266-4356(89)90048-x.
Twenty-five patients treated for malignant conditions of the head and neck were investigated for the development of oral radiation mucositis as well as oropharyngeal colonisation with fungi and Gram-negative bacilli. The colonisation rate of the patients increased from 20% to 80% during therapy. The patients were colonised mainly with fungi, but also to a lesser extent with Gram-negative bacilli. During radiotherapy free volatile fatty acids in saliva were determined by direct gas-liquid chromatography. The amounts of acetic, butyric and propionic acid decreased during radiotherapy and remained at low levels 6 months after therapy. Radiation induced mucositis was observed in 28% of the patients after 1 week of irradiation. After 3 weeks of therapy all patients showed varying grades of mucositis. In seven of the 19 survivors (36%) erythema was still present 6 months after radiotherapy.
对25例接受头颈部恶性疾病治疗的患者进行了调查，以研究口腔放射性粘膜炎以及口咽真菌和革兰氏阴性杆菌定植情况。治疗期间患者的定植率从20%升至80%。患者主要被真菌定植，但也有较少程度的革兰氏阴性杆菌定植。在放疗期间，通过直接气液色谱法测定唾液中的游离挥发性脂肪酸。放疗期间乙酸、丁酸和丙酸的含量下降，并在治疗后6个月维持在低水平。照射1周后，28%的患者出现放射性粘膜炎。治疗3周后，所有患者均表现出不同程度的粘膜炎。19名幸存者中有7名（36%）在放疗后6个月仍有红斑。
