Borthen L, Heimdahl A, Nord C E
Infection. 1984 Sep-Oct;12(5):349-54. doi: 10.1007/BF01651151.
Fourteen healthy individuals were studied regarding the oropharyngeal microflora. Seven subjects were given a non-absorbable multi-drug regimen, consisting of 1% polymyxin B, 3% neomycin and 3% amphotericin B, that was directed against aerobic gram-negative rods and fungi for local decontamination of the oropharynx. Seven others were given another multi-drug regimen consisting of 1% polymyxin B, 1% neomycin, 3% amphotericin B and 0.5% vancomycin, that also included an agent directed against gram-positive bacteria. Both decontamination regimens were found to protect from new colonization with fungi and gram-negative rods in the oropharynx. Suppression of gram-positive cocci was only observed in those subjects receiving the regimen containing vancomycin.
对14名健康个体的口咽微生物群进行了研究。7名受试者接受了一种不可吸收的多药方案，该方案由1%多粘菌素B、3%新霉素和3%两性霉素B组成，旨在针对需氧革兰氏阴性杆菌和真菌对口咽进行局部去污。另外7名受试者接受了另一种多药方案，该方案由1%多粘菌素B、1%新霉素、3%两性霉素B和0.5%万古霉素组成，其中还包括一种针对革兰氏阳性菌的药物。发现这两种去污方案都能防止口咽中新的真菌和革兰氏阴性杆菌定植。仅在接受含万古霉素方案的受试者中观察到革兰氏阳性球菌受到抑制。
