Jamil Zehra, Perveen Khalida, Malik Rabia, Avesi Lubna
Bilogical and Biomedical Sciences, Aga Khan University, Karachi, Pakistan.
Department of Anatomy, Dow University of Health Sciences, Karachi.
J Pak Med Assoc. 2016 Sep;66(9):1084-1088.
To evaluate the relationship between serum anti-Mullerian hormone and follicular dynamics in mice.
This experimental study was conducted in November, 2014 at the Dow University of Health Sciences, Karachi, and comprised laboratory-bred albino mice. They were sacrifised under anaesthesia and blood was collected via cardiac puncture to assess anti-Mullerian hormone while ovaries were collected for morphometric analyses. SPSS 19 was used for data analysis.
There were 20 mice with a mean weight of 25±1.89 grams, while weight of the ovaries obtained from these mice was 9.6±0.92mg. The mean serum anti-Mullerian hormone was 29.89±9.7ng/ml. On average, there were 87.8+13.54 primordial follicles, 51.85±8.36 primary, 20.35±5.57 secondary, 11.30±3.38 early antral and 3.05 ± 1.27 late antral follciles (p<0.001; p=0.06)..
Association of anti-Mullerian hormone with follicle dynamics reflected its role as a true ovarian reserve marker. Its assessment was of great significance in infertile women as well as young patients receiving chemotherapy.
评估小鼠血清抗苗勒管激素与卵泡动态变化之间的关系。
本实验研究于2014年11月在卡拉奇道健康科学大学进行，所用实验对象为实验室饲养的白化小鼠。对小鼠实施麻醉后处死，通过心脏穿刺采血以评估抗苗勒管激素水平，同时采集卵巢进行形态计量分析。采用SPSS 19进行数据分析。
共有20只小鼠，平均体重为25±1.89克，从这些小鼠获取的卵巢重量为9.6±0.92毫克。血清抗苗勒管激素平均水平为29.89±9.7纳克/毫升。平均而言，有87.8 + 13.54个原始卵泡、51.85±8.36个初级卵泡、20.35±5.57个次级卵泡、11.30±3.38个早期窦状卵泡和3.05±1.27个晚期窦状卵泡（p<0.001；p = 0.06）。
抗苗勒管激素与卵泡动态变化之间的关联反映了其作为真正的卵巢储备标志物的作用。其评估对不孕女性以及接受化疗的年轻患者具有重要意义。
