Norris T, Hawton K, Hamilton-Shield J, Crawley E
School of Social & Community Medicine, University of Bristol, Bristol, UK.
NIHR Bristol Biomedical Research Unit in Nutrition and University of Bristol, Bristol, UK.
Arch Dis Child. 2017 Jan;102(1):35-39. doi: 10.1136/archdischild-2016-311293. Epub 2016 Sep 21.
Identify the prevalence of obesity in patients with chronic fatigue syndrome (CFS) compared with healthy adolescents, and those identified with CFS in a population cohort.
Cross-sectional analysis of multiple imputed data.
Data from UK paediatric CFS/myalgic encephalomyelitis (CFS/ME) services compared with data collected at two time points in the Avon Longitudinal Study of Parents and Children (ALSPAC).
1685 adolescents who attended a CFS/ME specialist service between 2004 and 2014 and 13 978 adolescents aged approximately 13 years and 16 years participating in the ALSPAC study.
Body mass index (BMI) (kg/m), sex-specific and age-specific BMI Z-scores (relative to the International Obesity Task Force cut-offs) and prevalence of obesity (%).
Adolescents who had attended specialist CFS/ME services had a higher prevalence of obesity (age 13 years: 9.28%; age 16 years: 16.43%) compared with both adolescents classified as CFS/ME in ALSPAC (age 13 years: 3.72%; age 16 years: 5.46%) and those non-CFS in ALSPAC (age 13 years: 4.18%; age 16 years: 4.46%). The increased odds of obesity in those who attended specialist services (relative to non-CFS in ALSPAC) was apparent at both 13 years (OR: 2.31 (1.54 to 3.48)) and 16 years, with a greater likelihood observed at 16 years (OR: 4.07 (2.04 to 8.11)).
We observed an increased prevalence of obesity in adolescents who were affected severely enough to be referred to a specialist CFS/ME service. Further longitudinal research is required in order to identify the temporal relationship between the two conditions.
确定慢性疲劳综合征（CFS）患者与健康青少年以及人群队列中确诊为CFS的青少年相比肥胖的患病率。
对多重填补数据进行横断面分析。
来自英国儿科CFS/肌痛性脑脊髓炎（CFS/ME）服务机构的数据，与阿冯父母与儿童纵向研究（ALSPAC）在两个时间点收集的数据进行比较。
2004年至2014年间就诊于CFS/ME专科服务机构的1685名青少年，以及参与ALSPAC研究的13978名年龄约为13岁和16岁的青少年。
体重指数（BMI）（kg/m）、按性别和年龄划分的BMI Z评分（相对于国际肥胖特别工作组的临界值）以及肥胖患病率（%）。
与ALSPAC中分类为CFS/ME的青少年（13岁：3.72%；16岁：5.46%）和ALSPAC中未患CFS的青少年（13岁：4.18%；16岁：4.46%）相比，就诊于CFS/ME专科服务机构的青少年肥胖患病率更高（13岁：9.28%；16岁：16.43%）。就诊于专科服务机构的青少年肥胖几率增加（相对于ALSPAC中未患CFS的青少年）在13岁（比值比：2.31（1.54至3.48））和16岁时均很明显，16岁时可能性更大（比值比：4.07（2.04至8.11））。
我们观察到，受CFS影响严重到需转诊至CFS/ME专科服务机构的青少年肥胖患病率增加。需要进一步开展纵向研究以确定这两种情况之间的时间关系。
