Venkatesh Kusuma, Priyanka Tushar, Rukmini Niveditha Shankaran, Bisanna Jagannath
Professor, Kempegowda Institute of Medical Sciences , Bangalore, Karnataka, India .
Post Graduate Cum Tutor, Kempegowda Institute of Medical Sciences , Bangalore, Karnataka, India .
J Clin Diagn Res. 2016 Aug;10(8):ED12-4. doi: 10.7860/JCDR/2016/20150.8341. Epub 2016 Aug 1.
Osteosarcoma (OS), a common malignant tumour of the long bones, is rarely seen in the craniofacial region (5-8%). Though it's aetiology is unknown, previous radiotherapy, Pagets disease, Retinoblastoma and benign bone lesions such as fibrous dysplasia are considered as predisposing factors. It is seen commonly in adults between the third and fourth decades of life, in the Gnathic location mandible. We report a rare case of chondroblastic variant of OS of the right mandible, in a 35-year-old male, who underwent right segmental mandibulectomy with fibular graft reconstruction and is having disease free survival one and half years post surgery. Craniofacial OSs, are considered a separate category in view of their low histologic grade, less frequent metastases and better prognosis. Hence the diagnosis of this variant is important. This case is reported because of its rarity and typical histopathological features.
骨肉瘤（OS）是长骨常见的恶性肿瘤，在颅面部区域很少见（5-8%）。虽然其病因尚不清楚，但既往放疗、佩吉特病、视网膜母细胞瘤以及诸如骨纤维异常增殖症等良性骨病变被认为是诱发因素。骨肉瘤常见于30至40岁的成年人，位于颌骨部位的下颌骨。我们报告一例罕见的右下颌骨骨肉瘤软骨母细胞变型病例，患者为一名35岁男性，接受了右下颌骨节段性切除及腓骨移植重建术，术后无病生存一年半。鉴于颅面部骨肉瘤组织学分级低、转移频率低且预后较好，故被视为一个单独的类别。因此，对这种变型的诊断很重要。报告此病例是因其罕见性及典型的组织病理学特征。
