Boussouni Soufiane, Touré Gaoussou
Oral Surgery, Université de Paris, Paris, FRA.
Oral and Maxillofacial Surgery, Centre Hospitalier Intercommunal de Villeneuve Saint-Georges, Villeneuve Saint-Georges, FRA.
Cureus. 2021 Nov 26;13(11):e19929. doi: 10.7759/cureus.19929. eCollection 2021 Nov.
Osteosarcoma of the jaw only represents 0.5-1% of tumors of the facial mass. Due to its rarity, clinical diagnosis is thus difficult. The guidelines for this pathology remain unclear, and the need for neoadjuvant chemotherapy is still debated. This case report aims to describe a rare case of chondroblastic osteosarcoma in a 50-year-old woman on risedronate treated by neoadjuvant chemotherapy. The tumor extended from the mandibular left first premolar to the mandibular right canine. An excisional biopsy was performed, leading to a diagnosis of chondroblastic osteosarcoma. Neoadjuvant chemotherapy was ineffective, as it did not result in the shrinkage of the tumor. A pelvi-mandibulectomy with fibula free flap reconstruction of the mandible was subsequently successfully performed followed by radiotherapy.
颌骨骨肉瘤仅占面部肿块肿瘤的0.5 - 1%。由于其罕见性，临床诊断因此困难。这种病理的指导方针仍不明确，新辅助化疗的必要性仍存在争议。本病例报告旨在描述一名50岁正在服用利塞膦酸盐的女性发生软骨母细胞性骨肉瘤的罕见病例，该患者接受了新辅助化疗。肿瘤从下颌左侧第一前磨牙延伸至下颌右侧尖牙。进行了切除活检，诊断为软骨母细胞性骨肉瘤。新辅助化疗无效，因为它并未导致肿瘤缩小。随后成功进行了骨盆 - 下颌骨切除术及下颌骨游离腓骨瓣重建术，之后进行了放射治疗。
