Yuan Qing-Qing, Song Wei-Bin, Wang Wen-Qiong, Xuan Li-Jiang
a State Key Laboratory of Drug Research , Shanghai Institute of Materia Medica, Chinese Academy of Sciences , Shanghai , P.R. China.
b College of pharmacy , University of Chinese Academy of Sciences , Beijing , P.R. China.
Nat Prod Res. 2017 Feb;31(3):289-293. doi: 10.1080/14786419.2016.1233413. Epub 2016 Sep 23.
A new patchoulane-type sesquiterpenoid glycoside (1), together with five known sesquiterpenoids (2-6), was isolated from the roots of Croton crassifolius. Their structures were elucidated on the basis of spectroscopic methods. This is the first report about the sesquiterpenoid glycoside from C. crassifolius. All the isolated compounds 1-6 were evaluated for their cytotoxic activities against human tumour cell lines HL-60 and A549, but none showed significant activity.
从厚叶巴豆的根中分离出一种新的广藿香烷型倍半萜糖苷（1）以及五种已知的倍半萜（2 - 6）。通过光谱方法阐明了它们的结构。这是关于厚叶巴豆中倍半萜糖苷的首次报道。对所有分离得到的化合物1 - 6进行了针对人肿瘤细胞系HL - 60和A549的细胞毒性活性评估，但均未显示出显著活性。
