Mitchell J B, Stewart J
Department of Psychology, Concordia University, Montreal, Que., Canada.
Brain Res. 1989 Jul 3;491(1):116-27. doi: 10.1016/0006-8993(89)90093-0.
The concentrations of dopamine (DA) and a DA metabolite in a terminal field of the mesolimbic DA system, the nucleus accumbens, decreased after castration, an effect that was prevented by treatment with testosterone (T) or estradiol. After castration, DA concentrations were increased in the medial preoptic area, and were unchanged in the caudate-putamen, substantia nigra, and ventral tegmental area. Changes in DA and DA metabolite concentrations in the nucleus accumbens coincided with changes in measures of sexual arousal. Sexual experience did not affect DA concentrations, but did increase DA metabolism in the nucleus accumbens, and also increased the frequency of female-directed behavior in castrated males. These results suggest that T, or its aromatized metabolite, influences the mesolimbic DA system, and that this system is involved in mediating sexual arousability.
在中脑边缘多巴胺（DA）系统的终末区域伏隔核中，多巴胺（DA）及其一种代谢产物的浓度在去势后降低，而睾酮（T）或雌二醇治疗可防止这种效应。去势后，内侧视前区的DA浓度升高，而尾状核 - 壳核、黑质和腹侧被盖区的DA浓度没有变化。伏隔核中DA及其代谢产物浓度的变化与性唤起指标的变化一致。性经验不影响DA浓度，但会增加伏隔核中的DA代谢，并且还会增加去势雄性动物中针对雌性行为的频率。这些结果表明，睾酮或其芳香化代谢产物会影响中脑边缘DA系统，并且该系统参与介导性唤起能力。
