Mas M, Gonzalez-Mora J L, Louilot A, Solé C, Guadalupe T
Departamento de Fisiologia, Universidad de La Laguna, Tenerife, Spain.
Neurosci Lett. 1990 Mar 14;110(3):303-8. doi: 10.1016/0304-3940(90)90864-6.
This report describes the changes in extracellular levels of dopamine (DA) and dihydroxyphenylacetic acid (DOPAC) detected in the nucleus accumbens of male rats engaged in copulatory activity. They were monitored by using differential normal pulse voltammetry (DNPV) with electrochemically pretreated carbon fiber microelectrodes and numerical analysis of the catechol signal. The copulatory pattern displayed during the voltammetric recordings was similar to those recorded prior to surgery. Copulating animals showed a conspicuous increase in the DA and DOPAC electrochemical signals up to, respectively, 170% and 150% of baseline levels. This response was much attenuated when the experimental animals were exposed to either non-receptive castrated females or intact males. These data are consistent with the permissive role currently ascribed to the dopaminergic innervation of the n. accumbens in the selection and the initiation of behavioral adaptive sequences.
本报告描述了在进行交配活动的雄性大鼠伏隔核中检测到的多巴胺（DA）和二羟基苯乙酸（DOPAC）细胞外水平的变化。使用经电化学预处理的碳纤维微电极通过差分正常脉冲伏安法（DNPV）和儿茶酚信号的数值分析对它们进行监测。伏安记录期间显示的交配模式与手术前记录的相似。交配的动物显示DA和DOPAC电化学信号显著增加，分别高达基线水平的170%和150%。当实验动物暴露于非接受性阉割雌性或完整雄性时，这种反应会大大减弱。这些数据与目前归因于伏隔核多巴胺能神经支配在行为适应性序列的选择和启动中的允许作用一致。
