Rim15激酶和Sch9激酶参与了出芽酵母中核糖体自噬降解的诱导过程。
Rim15 and Sch9 kinases are involved in induction of autophagic degradation of ribosomes in budding yeast.
作者信息
Waliullah Talukdar Muhammad, Yeasmin Akter Mst, Kaneko Atsuki, Koike Naoki, Terasawa Mashu, Totsuka Takaya, Ushimaru Takashi
机构信息
a Graduate School of Science and Technology , Shizuoka University , Shizuoka , Japan.
b Department of Science, Graduate School of Integrated Science and Technology , Shizuoka University , Shizuoka , Japan.
出版信息
Biosci Biotechnol Biochem. 2017 Feb;81(2):307-310. doi: 10.1080/09168451.2016.1234928. Epub 2016 Sep 23.
Autophagic degradation of ribosomes is promoted by nutrient starvation and inactivation of target of rapamycin complex 1 (TORC1). Here we show that selective autophagic degradation of ribosomes (called ribophagy) after TORC1 inactivation requires the specific autophagy receptor Atg11. Rim15 protein kinase upregulated ribophagy, while it downregulated non-selective degradation of ribosomes.
核糖体的自噬性降解由营养饥饿和雷帕霉素靶蛋白复合物1（TORC1）失活所促进。在此我们表明，TORC1失活后核糖体的选择性自噬性降解（称为核糖体自噬）需要特定的自噬受体Atg11。Rim15蛋白激酶上调核糖体自噬，而它下调核糖体的非选择性降解。
Zotero 插件