Wang Yanlei, Qin Zhao, Buehler Markus J, Xu Zhiping
Applied Mechanics Laboratory, Department of Engineering Mechanics and Center for Nano and Micro Mechanics, Tsinghua University, Beijing 100084, China.
Laboratory for Atomistic and Molecular Mechanics, Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room 1-290, Cambridge, Massachusetts 02139, USA.
Nat Commun. 2016 Sep 23;7:12854. doi: 10.1038/ncomms12854.
The increasing interest in developing nanodevices for biophysical and biomedical applications results in concerns about thermal management at interfaces between tissues and electronic devices. However, there is neither sufficient knowledge nor suitable tools for the characterization of thermal properties at interfaces between materials of contrasting mechanics, which are essential for design with reliability. Here we use computational simulations to quantify thermal transfer across the cell membrane-graphene interface. We find that the intercalated water displays a layered order below a critical value of ∼1 nm nanoconfinement, mediating the interfacial thermal coupling, and efficiently enhancing the thermal dissipation. We thereafter develop an analytical model to evaluate the critical value for power generation in graphene before significant heat is accumulated to disturb living tissues. These findings may provide a basis for the rational design of wearable and implantable nanodevices in biosensing and thermotherapic treatments where thermal dissipation and transport processes are crucial.
对开发用于生物物理和生物医学应用的纳米器件的兴趣日益浓厚，这引发了人们对组织与电子设备之间界面热管理的关注。然而，对于力学性能截然不同的材料之间界面的热特性表征，既没有足够的知识，也没有合适的工具，而这些对于可靠设计至关重要。在此，我们使用计算模拟来量化跨细胞膜 - 石墨烯界面的热传递。我们发现，在约1纳米纳米限域的临界值以下，插层水呈现出层状有序结构，介导界面热耦合，并有效增强热耗散。此后，我们开发了一个分析模型，以评估石墨烯在大量热量积累干扰活组织之前的发电临界值。这些发现可能为在热耗散和传输过程至关重要的生物传感和热疗治疗中合理设计可穿戴和植入式纳米器件提供基础。
