Donker R A, Beuving G
Agricultural University, Department of Animal Husbandry, Wageningen, The Netherlands.
Br Poult Sci. 1989 Jun;30(2):361-9. doi: 10.1080/00071668908417157.
The effect of corticosterone on antibody production was studied in chicken lines selected for humoral immune response. 2. Twelve cockerels (33 days old) from lines selected for high or low antibody responses after immunisation with sheep red blood cells (SRBC) were implanted with mini-infusion pumps delivering corticosterone or vehicle continuously for 14 d. 3. Three days after implantation, the chickens were immunised intramuscularly with 0.25 ml packed SRBC. Blood samples were taken before implantation, before immunisation and 3, 5, 7 and 11 d after immunization. 4. Corticosterone infusion induced higher plasma corticosterone concentrations and heterophil/lymphocyte ratios than infusion of vehicle only. Growth was considerably depressed and relative weights of the thymus, bursa of Fabricius and spleen were less in the corticosterone-infused chickens. 5. An effect of corticosterone on antibody production could not be demonstrated, and differences between selection lines were unaffected.
在针对体液免疫反应进行选育的鸡品系中，研究了皮质酮对抗体产生的影响。2. 从经绵羊红细胞（SRBC）免疫后抗体反应高或低的选育品系中选取12只公鸡（33日龄），植入微型输注泵，连续14天持续输注皮质酮或赋形剂。3. 植入后3天，给鸡肌肉注射0.25 ml压积SRBC进行免疫。在植入前、免疫前以及免疫后3、5、7和11天采集血样。4. 与仅输注赋形剂相比，输注皮质酮导致血浆皮质酮浓度和异嗜性粒细胞/淋巴细胞比值更高。皮质酮输注组鸡的生长显著受抑，胸腺、法氏囊和脾脏的相对重量更小。5. 未证实皮质酮对抗体产生有影响，选育品系之间的差异也未受影响。
