Damase-Michel C, Tran M A, Montastruc J L
Laboratoire de pharmacologie médicale et Clinique INSERM U317, Faculté de médecine, Toulouse, France.
Can J Physiol Pharmacol. 1989 May;67(5):428-30. doi: 10.1139/y89-068.
Previous studies have shown that calcium channel blockers from the dihydropyridine group (such as nicardipine) induce an increase in sympathetic tone from a central origin in chronic sinoaortic-denervated (SAD) dogs. In the present study, we investigated to see if verapamil possesses such properties. The effects of acute injection of verapamil (0.2 mg/kg i.v.) were compared in normal and SAD conscious dogs. Verapamil induced a decrease in blood pressure in the two groups of animals, and an increase in heart rate and plasma catecholamines (noradrenaline and adrenaline) in normal but not in SAD dogs. Contrary to the dihydropyridine studies (nicardipine), we did not find any evidence for a centrally mediated sympathoexcitatory effect of verapamil in conscious SAD dogs.
先前的研究表明，二氢吡啶类钙通道阻滞剂（如尼卡地平）可使慢性去窦主动脉神经支配（SAD）犬的交感神经张力从中枢起源处增加。在本研究中，我们调查了维拉帕米是否具有此类特性。比较了急性注射维拉帕米（0.2mg/kg静脉注射）对正常和清醒SAD犬的影响。维拉帕米使两组动物的血压降低，使正常犬的心率和血浆儿茶酚胺（去甲肾上腺素和肾上腺素）增加，但对SAD犬无此作用。与二氢吡啶类研究（尼卡地平）相反，我们没有发现任何证据表明维拉帕米对清醒SAD犬有中枢介导的交感神经兴奋作用。
