Damase-Michel C, Valet P, Montastruc J L
Laboratoire de Pharmacologie Médicale et Clinique, UA 644 du CNRS, Faculté de Médecine, Toulouse, France.
Eur J Pharmacol. 1987 Oct 6;142(1):145-9. doi: 10.1016/0014-2999(87)90665-0.
Nicardipine-induced tachycardia is generally attributed to the involvement of the baroreflex. The effects of nicardipine on blood pressure (BP) and heart rate (HR) as well as on plasma catecholamine levels were studied in six conscious dogs made hypertensive by sinoaortic denervation. Nicardipine (50, 100 and 200 micrograms/kg i.v.) induced both a significant decrease in mean BP and a marked increase in HR in these dogs whereas the catecholamines rose significantly. Nicardipine-induced tachycardia cannot be explained by a baroreflex mechanism only. It is suggested that nicardipine induces an increase in HR and sympathetic tone, probably by a direct action on central cardiovascular mechanisms.
尼卡地平诱发的心动过速通常归因于压力感受器反射的参与。在6只通过去窦主动脉神经支配而导致高血压的清醒犬中，研究了尼卡地平对血压（BP）、心率（HR）以及血浆儿茶酚胺水平的影响。尼卡地平（静脉注射50、100和200微克/千克）可使这些犬的平均血压显著降低，心率显著升高，而儿茶酚胺水平则显著升高。尼卡地平诱发的心动过速不能仅用压力感受器反射机制来解释。提示尼卡地平可能通过直接作用于中枢心血管机制而导致心率和交感神经张力增加。
