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Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization.在红细胞同种免疫的小鼠模型中,白细胞介素-6受体-α信号传导驱动抗红细胞同种抗体产生和滤泡辅助性T细胞分化。
Haematologica. 2016 Nov;101(11):e440-e444. doi: 10.3324/haematol.2016.149278. Epub 2016 Aug 4.
2
Germinal center alloantibody responses are mediated exclusively by indirect-pathway CD4 T follicular helper cells.生发中心同种抗体反应完全由间接途径 CD4+滤泡辅助 T 细胞介导。
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3
Anti-interleukin 6 receptor antibodies attenuate antibody recall responses in a mouse model of allosensitization.抗白细胞介素6受体抗体可减弱同种致敏小鼠模型中的抗体回忆反应。
Transplantation. 2014 Dec 27;98(12):1262-70. doi: 10.1097/TP.0000000000000437.
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The Role of the Immunological Synapse in Differential Effects of APC Subsets in Alloimmunization to Fresh, Non-stored RBCs.免疫突触在 APC 亚群在异体免疫新鲜、非储存 RBC 中的差异效应中的作用。
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T Cell-Intrinsic IL-6R Signaling Is Required for Optimal ICOS Expression and Viral Control during Chronic Infection.T 细胞内源性 IL-6R 信号对于慢性感染期间最佳 ICOS 表达和病毒控制是必需的。
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The Nrf2 Activator CDDO-Imidazole Suppresses Inflammation-Induced Red Blood Cell Alloimmunization.Nrf2激活剂CDDO-咪唑可抑制炎症诱导的红细胞同种免疫。
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Independent effects of the hemoglobin-to-red blood cell distribution width ratio on 180-day mortality in critically ill patients with Gastrointestinal bleeding: analysis from the MIMIC-IV database.血红蛋白与红细胞分布宽度比值对危重症消化道出血患者180天死亡率的独立影响:来自MIMIC-IV数据库的分析
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Prior immunization against an intracellular antigen enhances subsequent red blood cell alloimmunization in mice.预先免疫细胞内抗原可增强小鼠随后的红细胞同种免疫。
Blood. 2023 May 25;141(21):2642-2653. doi: 10.1182/blood.2022016588.
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The Development and Consequences of Red Blood Cell Alloimmunization.红细胞同种免疫的发生与后果。
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Retention of functional mitochondria in mature red blood cells from patients with sickle cell disease.保留镰状细胞病患者成熟红细胞中的功能性线粒体。
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本文引用的文献

1
T cell-intrinsic role of IL-6 signaling in primary and memory responses.白细胞介素-6信号在初始和记忆反应中的T细胞内在作用。
Elife. 2014 May 19;3:e01949. doi: 10.7554/eLife.01949.
2
B and T cells collaborate in antiviral responses via IL-6, IL-21, and transcriptional activator and coactivator, Oct2 and OBF-1.B 和 T 细胞通过白细胞介素 6、白细胞介素 21 以及转录激活因子和共激活因子 Oct2 和 OBF-1 协同作用于抗病毒反应。
J Exp Med. 2012 Oct 22;209(11):2049-64. doi: 10.1084/jem.20111504. Epub 2012 Oct 8.
3
The origins, function, and regulation of T follicular helper cells.滤泡辅助性 T 细胞的起源、功能与调控
J Exp Med. 2012 Jul 2;209(7):1241-53. doi: 10.1084/jem.20120994.
4
ICOS receptor instructs T follicular helper cell versus effector cell differentiation via induction of the transcriptional repressor Bcl6.ICOS 受体通过诱导转录抑制因子 Bcl6 来指示 T 滤泡辅助细胞向效应细胞分化。
Immunity. 2011 Jun 24;34(6):932-46. doi: 10.1016/j.immuni.2011.03.023.
5
IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation.IL-21 和 IL-6 对于 B 细胞免疫的不同方面至关重要,并可冗余地诱导最佳滤泡辅助性 CD4 T 细胞(Tfh)分化。
PLoS One. 2011 Mar 14;6(3):e17739. doi: 10.1371/journal.pone.0017739.
6
In vivo regulation of Bcl6 and T follicular helper cell development.Bcl6 及滤泡辅助性 T 细胞发育的体内调控。
J Immunol. 2010 Jul 1;185(1):313-26. doi: 10.4049/jimmunol.0904023. Epub 2010 Jun 2.
7
Differences in wound healing in mice with deficiency of IL-6 versus IL-6 receptor.白细胞介素-6 缺陷型与白细胞介素-6 受体缺陷型小鼠的伤口愈合差异。
J Immunol. 2010 Jun 15;184(12):7219-28. doi: 10.4049/jimmunol.0901929. Epub 2010 May 10.
8
Transfusion of red blood cells after prolonged storage produces harmful effects that are mediated by iron and inflammation.长期储存后的红细胞输注会产生有害影响,这些影响是由铁和炎症介导的。
Blood. 2010 May 27;115(21):4284-92. doi: 10.1182/blood-2009-10-245001. Epub 2010 Mar 18.
9
Regulation of primary alloantibody response through antecedent exposure to a microbial T-cell epitope.通过预先接触微生物 T 细胞表位来调节原发性同种抗体反应。
Blood. 2010 May 13;115(19):3989-96. doi: 10.1182/blood-2009-08-238568. Epub 2010 Jan 19.
10
Storage of murine red blood cells enhances alloantibody responses to an erythroid-specific model antigen.储存鼠类红细胞增强了对红细胞特异性模型抗原的同种抗体反应。
Transfusion. 2010 Mar;50(3):642-8. doi: 10.1111/j.1537-2995.2009.02481.x. Epub 2009 Nov 9.

Interleukin-6 receptor-alpha signaling drives anti-RBC alloantibody production and T-follicular helper cell differentiation in a murine model of red blood cell alloimmunization.

作者信息

Arneja Abhinav, Salazar Juan E, Jiang Wenyu, Hendrickson Jeanne E, Zimring James C, Luckey Chance John

机构信息

Department of Pathology, University of Virginia, Charlottesville, VA, USA.

Department of Pathology, Brigham & Women's Hospital, Boston, MA, USA.

出版信息

Haematologica. 2016 Nov;101(11):e440-e444. doi: 10.3324/haematol.2016.149278. Epub 2016 Aug 4.

DOI:10.3324/haematol.2016.149278
PMID:27662015
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5394864/
Abstract
摘要