1例B细胞慢性淋巴细胞白血病患者出现短暂性inv(14)(q11q32)。

Appearance of a transient inv(14)(q11q32) in a case of B cell chronic lymphocytic leukemia.

作者信息

Schlegelberger B, Zech L, Euler H, Löffler H, Himmler A, Feller A

机构信息

Department of Human Genetics, Christian Albrechts-Universität, Kiel, West Germany.

出版信息

Cancer Genet Cytogenet. 1989 Aug;41(1):87-92. doi: 10.1016/0165-4608(89)90111-8.

DOI:10.1016/0165-4608(89)90111-8

PMID:2766254

Abstract

The inv(14)(q11q32) has been reported to be a specific chromosome aberration in T-cell chronic lymphocytic leukemia (T-CLL) and different types of T-cell lymphomas. Here, the first case of B-CLL with a clonal inv(14)(q11q32) in a phytohemagglutinin-stimulated bone marrow culture is presented. In a subsequent study 9 months later, tetradecanoyl-o-phorbol-13-acetate stimulated blood and bone marrow cultures revealed a clone with a t(1;11)(p13.2;q23.1) and an aberrant chromosome 17.

摘要

据报道，inv(14)(q11q32)是T细胞慢性淋巴细胞白血病（T-CLL）和不同类型T细胞淋巴瘤中的一种特定染色体畸变。本文报告了第一例在植物血凝素刺激的骨髓培养中出现克隆性inv(14)(q11q32)的B-CLL病例。在9个月后的后续研究中，十四烷酰佛波醇-13-乙酸酯刺激的血液和骨髓培养显示出一个具有t(1;11)(p13.2;q23.1)和异常17号染色体的克隆。