伴有inv(14)(q11q32)的双克隆B细胞慢性淋巴细胞白血病

Biclonal B-cell chronic lymphocytic leukemia with inv(14)(q11q32).

作者信息

Wong K F, So C C

机构信息

Department of Pathology, Queen Elizabeth Hospital, Hong Kong.

出版信息

Cancer Genet Cytogenet. 1997 Apr;94(2):135-7. doi: 10.1016/s0165-4608(96)00222-1.

DOI:10.1016/s0165-4608(96)00222-1

PMID:9109943

Abstract

Cytogenetic biclonality is a rare occurrence in chronic lymphocytic leukemia. A 59-year-old man was diagnosed to have B-cell chronic lymphocytic leukemia with typical morphology and immunophenotype (CD5+, CD19+, and CD23+). However, karyotypic analysis of the small lymphocytes showed the presence of two distinct unrelated clones, including one with inv(14).

摘要

细胞遗传学双克隆性在慢性淋巴细胞白血病中很少见。一名59岁男性被诊断为具有典型形态学和免疫表型（CD5+、CD19+和CD23+）的B细胞慢性淋巴细胞白血病。然而，对小淋巴细胞的核型分析显示存在两个不同的无关克隆，其中一个具有14号染色体倒位。