Varım Ceyhun, Acar Bilgehan Atılgan, Uyanık Mehmet Sevki, Acar Turkan, Alagoz Neslihan, Nalbant Ahmet, Kaya Tezcan, Ergenc Hasan
Department of Internal Medicine, Sakarya University Medicine Faculty, Sakarya, Turkey.
Department of Neurology, Sakarya University Medicine Faculty, Sakarya, Turkey.
Singapore Med J. 2016 Sep;57(9):514-6. doi: 10.11622/smedj.2016154.
Restless legs syndrome (RLS), also known as Willis-Ekbom disease, is characterised by abnormal sensations in the legs as well as dysaesthesia. Although the aetiology of RLS has not yet been determined, it may be associated with systemic inflammation. The neutrophil-to-lymphocyte ratio (NLR) is a new and simple marker indicating systemic inflammation. The present study aimed to investigate the relationship between systemic inflammation and RLS through the use of the NLR.
A total of 75 newly diagnosed patients with RLS and 56 healthy control subjects were included in the study. Baseline NLR was calculated by dividing the absolute neutrophil count by the absolute lymphocyte count. The NLRs of the two groups were compared.
There were no significant differences in gender and age between the two groups. The NLR was 1.96 ± 0.66 in the patient group and 1.67 ± 0.68 in the control group (p = 0.005). Receiver operating characteristic analysis was performed to determine the cut-off value of NLR to predict RLS. The NLR was predictive at 1.58 with a 64% sensitivity and 50% specificity (95% confidence interval 0.55-0.74, area under curve 0.648 ± 0.05). The NLR was found to be statistically higher in patients with RLS and may be used to predict RLS.
The aetiology of RLS remains undetermined. The present study showed that systemic inflammation may play a role in RLS. However, RLS could also be associated with systemic inflammatory diseases. This relationship is supported by high NLR values, which are related to chronic systemic inflammation.
不宁腿综合征（RLS），也称为威利斯-埃克博姆病，其特征为腿部异常感觉以及感觉异常。尽管RLS的病因尚未确定，但可能与全身炎症有关。中性粒细胞与淋巴细胞比值（NLR）是一种新的、简单的指示全身炎症的标志物。本研究旨在通过使用NLR来探究全身炎症与RLS之间的关系。
本研究共纳入75例新诊断的RLS患者和56例健康对照者。通过将绝对中性粒细胞计数除以绝对淋巴细胞计数来计算基线NLR。比较两组的NLR。
两组在性别和年龄方面无显著差异。患者组的NLR为1.96±0.66，对照组为1.67±0.68（p = 0.005）。进行受试者工作特征分析以确定预测RLS的NLR临界值。NLR为1.58时具有预测性，敏感性为64%，特异性为50%（95%置信区间0.55 - 0.74，曲线下面积0.648±0.05）。发现RLS患者的NLR在统计学上更高，可用于预测RLS。
RLS的病因仍未确定。本研究表明全身炎症可能在RLS中起作用。然而，RLS也可能与全身炎症性疾病有关。这种关系得到高NLR值的支持，高NLR值与慢性全身炎症相关。
