不安腿综合征患者心血管疾病风险升高。
Elevated Cardiovascular Disease Risk in Patients with Restless Legs Syndrome.
作者信息
Abuş Sabri, Kapıcı Yaşar, Ayhan Selçuk, Arık Ali
机构信息
Department of Cardiology, Adıyaman Training and Research Hospital, Adıyaman, Turkey.
Department of Psychiatry, Kahta State Hospital, Adıyaman, Turkey.
出版信息
Alpha Psychiatry. 2023 May 1;24(3):95-99. doi: 10.5152/alphapsychiatry.2023.221043. eCollection 2023 May.
OBJECTIVE
There are studies in the literature that link restless legs syndrome with increasing cardiovascular disease risk. The reason for this was that increased sympathomimetic activation in restless legs syndrome causes tachycardia, hypertension, and autonomic instability. We intended to assess the cardiovascular disease risk in patients with restless legs syndrome using electrocardiogram parameters.
METHODS
The present investigation compared the demographic characteristics, electrocardiogram variables, and lab results of 40 patients diagnosed with restless legs syndrome with 43 healthy controls.
RESULTS
Restless legs syndrome patients had a higher frontal QRS-T angle than healthy control patients. Restless legs syndrome patients had lower hemoglobin, neutrophil, lymphocyte, basophil, albumin, and high-density lipoprotein cholesterol levels. There was a significant increase in eosinophil, platelet, C-reactive protein, total cholesterol, low-density lipoprotein cholesterol, platelet-to-lymphocyte ratio, monocyte-to-lymphocyte ratio, and C-reactive protein-to-albumin ratio values in patients with restless legs syndrome. The frontal QRS-T angle is highly correlated with the neutrophil-to-lymphocyte ratio ( = .001). Similarly, monocyte-to-lymphocyte ratio and C-reactive protein-to-albumin ratio values were significantly correlated with frontal QRS-T ( = .011 and = .24).
CONCLUSION
The fact that frontal QRS-T angle and neutrophil-to-lymphocyte ratio were correlated in the restless legs syndrome group in our study suggests that the inflammatory process may have increased the risk of cardiovascular disease in restless legs syndrome patients. Our findings show that the frontal QRS-T angle is high in restless legs syndrome patients. We conclude that C-reactive protein-to-albumin ratio, neutrophil-to-lymphocyte ratio, and monocyte-to-lymphocyte ratio are higher in the restless legs syndrome patient group and are related to cardiovascular disease risk.
目的
文献中有研究将不宁腿综合征与心血管疾病风险增加联系起来。其原因在于不宁腿综合征中交感神经兴奋增强会导致心动过速、高血压和自主神经不稳定。我们旨在利用心电图参数评估不宁腿综合征患者的心血管疾病风险。
方法
本研究比较了40例诊断为不宁腿综合征的患者与43例健康对照者的人口统计学特征、心电图变量和实验室检查结果。
结果
不宁腿综合征患者的额面QRS-T角高于健康对照患者。不宁腿综合征患者的血红蛋白、中性粒细胞、淋巴细胞、嗜碱性粒细胞、白蛋白和高密度脂蛋白胆固醇水平较低。不宁腿综合征患者的嗜酸性粒细胞、血小板、C反应蛋白、总胆固醇、低密度脂蛋白胆固醇、血小板与淋巴细胞比值、单核细胞与淋巴细胞比值以及C反应蛋白与白蛋白比值均显著升高。额面QRS-T角与中性粒细胞与淋巴细胞比值高度相关（=0.001）。同样，单核细胞与淋巴细胞比值和C反应蛋白与白蛋白比值与额面QRS-T显著相关（=0.011和=0.24）。
结论
我们的研究中不宁腿综合征组额面QRS-T角与中性粒细胞与淋巴细胞比值相关这一事实表明，炎症过程可能增加了不宁腿综合征患者的心血管疾病风险。我们的研究结果表明，不宁腿综合征患者的额面QRS-T角较高。我们得出结论，不宁腿综合征患者组的C反应蛋白与白蛋白比值、中性粒细胞与淋巴细胞比值和单核细胞与淋巴细胞比值较高，且与心血管疾病风险相关。
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