Anagnostis P, Boboridis K, Adamidou F, Kita M
Department of Endocrinology and Diabetes, Hippokration Hospital of Thessaloniki, Sarantaporou 10, 54640, Thessaloníki, Greece.
1st University Department of Ophthalmology, Aristotle University of Thessaloniki, Thessaloníki, Greece.
J Endocrinol Invest. 2017 Mar;40(3):257-261. doi: 10.1007/s40618-016-0555-0. Epub 2016 Sep 23.
BACKGROUND/AIMS: The natural course of Graves' orbitopathy (GO) has been poorly documented. The aim of this review is to provide current knowledge regarding the natural course of mild GO, trying to address the issue of whether and to what extent it constitutes a chronic remitting or transient disease.
We systematically searched PubMed for English language publications until August 2016 under the following terms: "Graves' orbitopathy" OR "Graves' ophthalmopathy" OR "thyroid eye disease" AND "natural course" OR "natural history".
Few studies have investigated the course of mild orbital disease in patients with GO. Large controlled trials are lacking and data can be extracted mainly from small retrospective and some prospective studies, after excluding patients who had received radioiodine for thyrotoxicosis or surgical treatment for GO. In general, more than half of GO patients may show spontaneous improvement in their clinical features, whereas no safe conclusions can be drawn with regard to complete resolution, with percentages ranging from 6 to 58 %.
The question whether mild GO is a remitting, albeit chronic disease, or even a transient event in the course of Graves' disease, remains currently unanswered.
背景/目的：格雷夫斯眼眶病（GO）的自然病程鲜有文献记载。本综述的目的是提供关于轻度GO自然病程的当前知识，试图解决它是否以及在多大程度上构成一种慢性缓解或短暂性疾病的问题。
我们在PubMed上系统检索截至2016年8月的英文出版物，检索词如下：“格雷夫斯眼眶病”或“格雷夫斯眼病”或“甲状腺眼病”以及“自然病程”或“自然史”。
很少有研究调查GO患者轻度眼眶疾病的病程。缺乏大型对照试验，数据主要可从小型回顾性研究和一些前瞻性研究中提取，这些研究排除了因甲状腺毒症接受放射性碘治疗或因GO接受手术治疗的患者。一般来说，超过一半的GO患者临床特征可能会自发改善，而关于完全缓解尚无可靠结论，缓解率在6%至58%之间。
轻度GO是一种缓解性疾病（尽管是慢性的），还是甚至只是格雷夫斯病病程中的一个短暂事件，目前尚无定论。
