L-核糖异构酶和甘露糖-6-磷酸异构酶：用于 L-核糖生产的特性和应用。
L-Ribose isomerase and mannose-6-phosphate isomerase: properties and applications for L-ribose production.
机构信息
College of Food Science and Light Industry, Nanjing Tech University, Nanjing, China.
State Key Laboratory of Materials-Oriented Chemical Engineering, Nanjing, China.
出版信息
Appl Microbiol Biotechnol. 2016 Nov;100(21):9003-9011. doi: 10.1007/s00253-016-7834-8. Epub 2016 Sep 23.
L-Ribose is a synthetic L-form monosaccharide. It is a building block of many novel nucleotide analog anti-viral drugs. Bio-production of L-ribose relies on a two-step reaction: (i) conversion of L-arabinose to L-ribulose by the catalytic action of L-arabinose isomerase (L-AI) and (ii) conversion of L-ribulose to L-ribose by the catalytic action of L-ribose isomerase (L-RI, EC 5.3.1.B3) or mannose-6-phosphate isomerase (MPI, EC 5.3.1.8, alternately named as phosphomannose isomerase). Between the two enzymes, L-RI is a rare enzyme that was discovered in 1996 by Professor Izumori's group, whereas MPI is an essential enzyme in metabolic pathways in humans and microorganisms. Recent studies have focused on their potentials for industrial production of L-ribose. This review summarizes the applications of L-RI and MPI for L-ribose production.
L-核糖是一种合成的 L 型单糖。它是许多新型核苷酸类似物抗病毒药物的结构单元。L-核糖的生物生产依赖于两步反应：（i）L-阿拉伯糖异构酶（L-AI）催化作用下将 L-阿拉伯糖转化为 L-核酮糖，和（ii）L-核糖异构酶（L-RI，EC 5.3.1.B3）或甘露糖-6-磷酸异构酶（MPI，EC 5.3.1.8，也称为磷酸甘露糖异构酶）催化作用下将 L-核酮糖转化为 L-核糖。在这两种酶中，L-RI 是一种罕见的酶，于 1996 年由 Izumori 教授的研究小组发现，而 MPI 是人类和微生物代谢途径中的必需酶。最近的研究集中在它们在 L-核糖工业生产中的潜力。本文综述了 L-RI 和 MPI 在 L-核糖生产中的应用。
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