“冷切肉”被纳入昼夜节律调节机制的丰富体系之中。
'Cold cuts' added to the circadian smorgasbord of regulatory mechanisms.
作者信息
Green Carla B
机构信息
University of Texas Southwestern Medical Center, Dallas, Texas 75390, USA.
出版信息
Genes Dev. 2016 Sep 1;30(17):1909-10. doi: 10.1101/gad.289587.116.
Abstract
In mammals, rhythms in body temperature help to entrain and synchronize circadian rhythms throughout the organism, and the cold-inducible RNA-binding protein (CIRBP) is one of the mediators of these daily temperature changes. Cirbp mRNA expression is regulated by the daily subtle rhythms in body temperature, and a new study by Gotic and colleagues (pp. 2005-2017) reveals a surprising and novel mechanism that involves temperature-dependent enhancement of splicing efficiency.
摘要
在哺乳动物中，体温节律有助于在整个机体中诱导并同步昼夜节律，而冷诱导RNA结合蛋白（CIRBP）是这些日常体温变化的介质之一。Cirbp mRNA的表达受体温每日细微节律的调节，戈蒂克及其同事进行的一项新研究（第2005 - 2017页）揭示了一种惊人的新机制，该机制涉及温度依赖性的剪接效率增强。
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本文引用的文献
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Temperature regulates splicing efficiency of the cold-inducible RNA-binding protein gene Cirbp.温度调节冷诱导RNA结合蛋白基因Cirbp的剪接效率。
Genes Dev. 2016 Sep 1;30(17):2005-17. doi: 10.1101/gad.287094.116. Epub 2016 Sep 15.
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