Department of Neurobiology and Physiology, Northwestern University, Evanston, IL 60208-3520, USA.
Science. 2010 Oct 15;330(6002):379-85. doi: 10.1126/science.1195262.
Environmental temperature cycles are a universal entraining cue for all circadian systems at the organismal level with the exception of homeothermic vertebrates. We report here that resistance to temperature entrainment is a property of the suprachiasmatic nucleus (SCN) network and is not a cell-autonomous property of mammalian clocks. This differential sensitivity to temperature allows the SCN to drive circadian rhythms in body temperature, which can then act as a universal cue for the entrainment of cell-autonomous oscillators throughout the body. Pharmacological experiments show that network interactions in the SCN are required for temperature resistance and that the heat shock pathway is integral to temperature resetting and temperature compensation in mammalian cells. These results suggest that the evolutionarily ancient temperature resetting response can be used in homeothermic animals to enhance internal circadian synchronization.
环境温度周期是生物体水平上所有生物钟的普遍授时线索，除了恒温脊椎动物。我们在这里报告，对温度授时的抗性是视交叉上核（SCN）网络的特性，而不是哺乳动物钟的细胞自主特性。这种对温度的差异敏感性允许 SCN 驱动体温的昼夜节律，然后作为整个身体中细胞自主振荡器的普遍授时线索。药理学实验表明，SCN 中的网络相互作用对于温度抗性是必需的，并且热休克途径是哺乳动物细胞中温度重置和温度补偿的组成部分。这些结果表明，进化上古老的温度重置反应可用于恒温动物，以增强内部生物钟同步。
